Value of arterial blood gas analysis in patients with acute dyspnea an observational study 英文参考文献.docVIP
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Value of arterial blood gas analysis in patients with acute dyspnea an observational study 英文参考文献
Burrietal.CriticalCare2011,15:R145
/content/15/3/R145
RESEARCH
OpenAccess
Valueofarterialbloodgasanalysisinpatients
withacutedyspnea:anobservationalstudy
EmanuelBurri1,2,MihaelPotocki1,BeatriceDrexler1,PhilippSchuetz1,AlexandreMebazaa1,3,UlrikeAhlfeld1,
CatharinaBalmelli1,CorinnaHeinisch1,MarkusNoveanu1,TobiasBreidthardt1,NoraSchaub1,TobiasReichlin1and
ChristianMueller1*
Abstract
Introduction:Thediagnosticandprognosticvalueofarterialbloodgasanalysis(ABGA)parametersinunselected
patientspresentingwithacutedyspneatotheEmergencyDepartment(ED)islargelyunknown.
Methods:Weperformedapost-hocanalysisoftwodifferentprospectivestudiestoinvestigatethediagnosticand
prognosticvalueofABGAparametersinpatientspresentingtotheEDwithacutedyspnea.
Results:Weenrolled530patients(medianage74years).ABGAparameterswereneitherusefultodistinguish
betweenpatientswithpulmonarydisordersandothercausesofdyspneanortoidentifyspecificdisorders
responsiblefordyspnea.Onlyinpatientswithhyperventilationfromanxietydisorder,thediagnosticaccuracyofpH
andhypoxemiarenderedvaluablewithanareaunderthereceiveroperatingcharacteristicscurve(AUC)of0.86.
PatientsinthelowestpHtertilemoreoftenrequiredadmissiontointensivecareunit(28%vs12%inthefirst
tertile,P0.001)andhadhigherin-hospital(14%vs5%,P=0.003)and30-daymortality(17%vs7%,P=0.002).
Cumulativemortalityratewashigherinthefirst(37%),thaninthesecond(28%),andthethirdtertile(23%,P=
0.005)during12monthsfollow-up.pHatpresentationwasanindependentpredictorof12-monthmortalityin
multivariableCoxproportionalhazardanalysisbothforpatientswithpulmonary(P=0.043)andnon-pulmonary
disorders(P=0.038).
Conclusions:ABGAparametersprovidelimiteddiagnosticvalueinpatientswithacutedyspnea,butpHisan
independentpredictorof12monthsmortality.
Introduction
e.g.AHF,mightevenbehazardousforpatientswithother
Patients presenting totheemergency department (ED) conditionssuchasexacerbatedCOPDorpneumonia[5].
withacutedyspnearequirearapiddiagnosticworkupto Atpresentation totheED,arterial bloodgas
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