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Expression of POU-domain transcription factor, Oct-6, in schizophrenia, bipolar disorder and major depression.doc

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Expression of POU-domain transcription factor, Oct-6, in schizophrenia, bipolar disorder and major depression

BMC Psychiatry BioMedCentral Research article Open Access Expression of POU-domain transcription factor, Oct-6, in schizophrenia, bipolar disorder and major depression Kirenjeet Ubhi and Jack Price* Address: Institute of Psychiatry, Kings College London, Denmark Hill, London, UK Email: Kirenjeet Ubhi - spnekju@iop.kcl.ac.uk; Jack Price* - j.price@iop.kcl.ac.uk * Corresponding author Published: 24 October 2005 Received: 15 July 2005 Accepted: 24 October 2005 BMC Psychiatry 2005, 5:38 doi:10.1186/1471-244X-5-38 This article is available from: /1471-244X/5/38 ? 2005 Ubhi and Price; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Abstract Background: The POU-domain transcription factor Oct-6 has been reported to be differentially expressed between schizophrenic and control post-mortem brains. In this study, we attempted to replicate this finding and to discover whether Oct-6 was also dysregulated in bipolar disorder and major depression. Methods: Oct-6 mRNA and protein expression were determined by in-situ hybridization and immunohistochemistry respectively in sections of post-mortem brain. Results: We did not observe any differences in Oct-6 expression between any of the groups under study. Oct-6 mRNA and protein was identically expressed in the hippocampal and cortical regions of most specimens in all groups, including controls. Conclusion: Oct-6 is, therefore, unlikely to be a specific marker for any psychological disorder; rather its expression in controls suggests that it is normally expressed in most adult brains. Background required for the timely initiation of myelination [2]. Oct- 6 has also been shown to be expressed in postmitotic neu- rons of the developing rodent telencephalon