重组人酸性成纤维细胞生长因子持续冲洗联合负压引流治疗难愈性皮肤溃疡的效果观察.pdfVIP

中国当代医药 2015 年3 月第22 卷第8 期 ·临床研究· 重组人酸性成纤维细胞生长因子持续冲洗联合 负压引流治疗难愈性皮肤溃殇的效果观察 黄春晓 陈仕新 谆美华 广东省阳江市人民医院综合外科，广东阳江 5295∞ [摘要]目的研究重组人酸性成纤维细胞生长因子(rh-aFGF)持续冲洗联合负压引流治疗难愈性皮肤溃癌的临床 效果。方法收集2011 年 1 月 -2013 年 12 月本院收治的皮肤渍痛难愈性创面患者 55 例，按照交替法分为观察 组(29 例)和对照组(26 例)。观察组在冲洗液中加入5 支 rh-aFGF，即应用 rh-aFGF 持续冲洗联合负压引流进行 治疗;对照组在冲洗液中加入等量生理盐水，联合负压引流进行治疗。记录治疗前后患者的皮肤深部组织外露面 积及溃殇创面，由此计算皮肤溃癌伤腔容积减少值和创面愈合率。结果观察组皮肤渍癌创面在植皮或者短期 换药后愈合，对照组皮肤溃殇创面要经过皮瓣移植或较长时间换药才有好转。两组创面愈合率、伤腔容积减少值 比较，差异有统计学意义(P0.05) 。结论 rh-aFGF 持续冲洗联合负压引流治疗难愈性皮肤溃瘤，可加速皮肤溃 痛创面愈合，使达到替代治疗的目的，具有一定的临床意义，值得推广应用。 [关键词]重组人酸性成纤维细胞生长因子;皮瓣移植;难愈性皮肤溃荡;负压引流 [中固分类号1 R641 [文献标识码1 A [文章编号11674-4721(2015)03(b)-0029-03 EfTect observation of recombinant human acidic fibroblast growth factor for continuous irrigation combined with negative pressure drainage in treatment of refractory skin ulcer HUANG Chun-xiω CHEN Shi-xin TAN Mei-hua Department of General Surgery,Peoples Hospital of Yangjiang City in Guangdong Province ,Yangjiang 5295∞，China [Abstract] Obj配tive To study the effect of recombinant human acidic fibroblast growth factor (rh-aFGF) for continu- ous irrigation combined with negative pressure drainage in the treatment of refractory skin ulcers. Methods 55 patients with refractory wound in skin ulcer百 treated in our hospital from January 2011 to December 2013 were selected,and were altemately divided into observation group (n::::29) and control 伊oup (n::::26).rh-aFGF for continuous irrigation com- bined with negative pressure drainage was applied to observation group.The same volume of saline was added into the irrigation solution,and combined wi也 negative pressu