严重少精子症和无精子症患者染色体核型分析.pdfVIP

• 14 • 甘肃医药2创9 1ì= 2 月第28 卷第1 期 Gansu Medical Joumal ,Feb 2∞9 ， Vol. 28 ,No.l 翩翩回in 阳ere head injury[ J]. J Neures吨，汩汩，92 (1 ):1 -6. [10] Young B ，伽 L， Demp呵 R， et al. Relationship betw嗣 brúnÎ船 [9] 章翔，费舟，王占样，等.重型颅脑损伤i临床救治经验[J] .中华神 jured 归四18[ 1]. Ann S吨，1998 ， 210(3) :466 -473. 经外科疾病研究杂志，2∞3 ， 2(3) :206. 严重少精子症和无精子症患者染色体核型分析 张洲师娟于周寒鹰强荣 [摘要l 目的:探讨男性严重少精子症和无精子症与染色体异常的关系。方法:对364 例严重少精子症和无精子症患者进行 外周血淋巴细胞培养，G 显带染色体核型分析。结果:严重少精子症和无稿子症异常染色体检出率分别为6.29% (9/143) 、11. 76% (26/221) 。严重少精子症以染色体易位为主77.78% (719) ， 无精子症以染色体数目畸变占大多数88.46% (23/26) 。结论:染色体 异常是导致严重少精子症和无精子症的重要原因之一，在卵胞浆内单精子显微注射治疗前进行染色体核型分析是必要的。 【关键词]少精子症;无精子症;染色体核型 中图分类号:R71 l. 6. Q343.γ44 文献标识码:A 文章编号:1∞4 -2725(2α别01-∞14-03 J ChromosomaI 1m巧。严s anaIysis on patients with severe oligospermia and azo由pennia ZHANG Z1wu • 2 , SHl Juan 四 zi2， ZHOU Han-作矿， QIANG ro Tlfl 1. Xi ím Jiaotong university 时∞，1 of medicine , Xi an 71∞61 China; 2. M耐mal and child health hospital of Shaanxi province , Xian 71仪lO3 China [Abstract]Objective: To study 由e re1ation between severe 01iglωpermi也阳帽严rmia and abnormal chromosome kary吻阳. Metbods: The periphery blood 1ymphocyte was cultured and the G - banding chromωome w翩翩alyzed on 394 male patients wi也 the severe olig叩lI­ mia and azo倒permia. 倒.tIts: 讪le incidence of abnormal chromω。me karyotype was 6.29% or 9/143 in patients wi由 severe olig菌严rmia b-J the G - banding , which ac∞unt for 77. 78 % or 7/9 in chromosome trans1ocation. The incidence of abnormal chrom跚跚karyotype was 11.76% or 26/221 in patients wi也 azoospermia by 也G - banding, which ac∞unt for 88.46% or 23/26 in numerical chr跚跚me aherra- tion . Conclusions: Chrom佣omal abnormalities may dramatically cause severe oligospermia and az蹦permia. It is very nec甜町to take 由e chrom跚跚karyotype examination on patients wi由