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抗体新概念 Epitomics兔单克隆抗体及其在蛋白研究中的优势探讨 1st Rabbit fusion partner cell from transgenic rabbit Katherine Knigh Loyola University, Chicago Rabbit Recognizes more Epitopes Comparison of rabbit and murine immune responses A Random Collection Of RabMAbs Have Extremely High Affinities Comparison of three commercially available anti-HER2 Abs in paraffin embedded human breast cancer tissue samples Anti-MCM2 RabMab,YCA-R4120 Phospho-specific RabMAbs Detecting Signal Transduction Events Saving Time Resources Eliminating the Need of “Surrogate” Antibodies A different mechanism of diversification and affinity maturation compared to rodents and humans One vH gene is predominantly used; Extensive somatic gene conversion and point mutations Affinity maturation continues for a longer time period (15 days post-immunization) Rabbit CDRs are much more diverse than rodents and humans Greater variation in length and sequence, especially in CDR3 Light chain CDR’s more variable Light chain contributes more to antibody affinity c-Jun Dual Detection ELISA Kit PEG Elisa Kit Epitomics RabMAb Thanks! High Quality assurance : IHC 3 Tissue Micro-arrays for IHC application test : Human Normal TMA, Human Tumor TMA Mouse Normal TMA Over 100 Tissues used HPA Approved Rabbit Monoclonals Epitomics has submitted over 150+ monoclonal antibodies to Swedish Human Protein Atlas (HPA) Program What is Human Protein Atlas (HPA)? A publically available online database Systematic exploration of the human proteome using Antibody-Based Proteomics. Antibodies were additionally IHC screened on eight TMAs representing 576 different human tissue cores. Shows expression and localization of proteins in a large variety of normal human tissues and cancer cells. Maintained Swedish Human Proteome Resource (HPR) Center. Founded in 2001 Over 1600 reagent grade specific RabMAbs Over 120 diagnostic grade specific RabMAbs 2 RabMAbs lead in preclinical drug development. Book Patent about RabMAb… 75— KDa 1
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