重组人透明质酸酶有助于儿童皮下输液治疗.pdf

论 著 重组人透明质酸酶有助于儿童皮下输液治疗 a,b c d e Coburn H. Allen, MD , Lisa S. Etzwiler, MD , Melissa K. Miller, MD , George Maher, DO , Sharon Mace, MDf g h i , Mark A. Hostetler, MD, MPH , Sharon R. Smith, MD , Neil Reinhardt, MD , j k Barry Hahn, MD , George Harb, MD for the INcreased Flow Utilizing Subcutaneously- Enabled-(INFUSE) Pediatric Rehydration Study Collaborative Research Group Sections of a Emergency Medicine; b Infectious Diseases, Department of Pediatrics, Baylor College of Medicine and Texas Childrens Hospital, Houston, Texas; c Department of Emergency Medicine, St Johns Mercy Childrens Hospital, St Louis, Missouri; d Emergency Medical Services, Childrens Mercy Hospital, Kansas City, Missouri; e Pediatric Hospitalist Service, Memo- rial Childrens Hospital, South Bend, Indiana; f Department of Emergency Medicine, Cleveland Clinic, Cleveland, Ohio; g Department of Pediatrics, University of Chicago, Chicago, Illinois; hDivision of Emergency Medicine, Department of Pediatrics, Connecticut Childrens Medical Center, Hartford, Connecticut; i Pediatric Emergency Department, Tampa General Hospital, Tampa, Florida; j Department of Emergency Medicine, Staten Island University Hospital, Staten Island, New York; kDepartment of Medication Delivery, Baxter Healthcare, Deerfield, Illinois 研究背景 研究新知 当静脉输液困难时可以采用皮下输液。添加透明质酸 首次将rHuPH20 应用于儿科轻/ 中度脱水 酶可暂时提高皮下组织的通透性，加快皮下液体的吸 患儿的治疗，显示出良好的疗效、安全 收。rHuPH20 在成人中的应用被证实是安全而有效 性和耐受性， 临床医师和家长均易于接 的。 受。 摘 要 目的 增加液体流量儿科研究(INFUSE) 的设计目的