绿原酸抗炎镇痛解热.pdf

2236 Biol. Pharm. Bull. 29(11) 2236—2240 (2006) Vol. 29, No. 11 Evaluation of the Anti-inflammatory, Analgesic and Antipyretic Activities of the Natural Polyphenol Chlorogenic Acid Michel David dos SANTOS,a Maria Camila ALMEIDA,b,1) Norberto Peporine LOPES,a and Glória Emília Petto de SOUZA*,a a University of São Paulo, Faculty of Pharmaceutical Sciences of Ribeirão Preto; Avenida do Café s/n°, Campus Universitário da USP, Ribeirão Preto-SP 14040-903, Brazil: and b University of São Paulo, Medical School of Ribeirão Preto; Avenida dos Bandeirantes 3900, Campus Universitário da USP, Ribeirão Preto-SP 14049–900, Brazil. Received May 13, 2006; accepted August 23, 2006 Phenolic compounds are numerous and ubiquitous in the plant kingdom, being particularly present in health-promoting foods. Epidemiological evidences suggest that the consumption of polyphenol-rich foods re- duces the incidence of cancer, coronary heart disease and inflammation. Chlorogenic acid (CGA) is one of the most abundant polyphenol compounds in human diet. Data obtained from in vivo and in vitro experiments show that CGA mostly presents antioxidant and anti-carcinogenic activities. However, the effects of CGA on the in- flammatory reaction and on the related pain and fever processes have been explored less so far. Therefore, this study was designed to evaluate the anti-inflammatory, antinociceptive and antipyretic activities of CGA in rats. In comparison to control, CGA at doses 50 and 100 mg/kg inhibited carrageenin-induced paw edema beginning at the 2nd hour of the experimental procedure. Furthermore, at doses 50 and 100 mg/kg CGA also inhibited the number of flinches in the late phase of formalin-induced