异甘草素微胶囊的制备及释放性的研究.pdfVIP

现代食品科技 Modern Food Science and Technology 2010, Vol.26, No.10 异甘草素微胶囊的制备及释放性的研究 周锦霞 1 1 1,2 ，伍林 ，王建国 （1.武汉科技大学应用化学研究所，湖北武汉 430081）（2.九江学院化学化工学院，江西九江 332005） 摘要：本文以微胶囊的包埋率和载药量为考察对象，采用内源乳化法制备了异甘草素微胶囊并对其体外释药性进行了研究。其 最佳制备条件为：海藻酸钠的浓度为2% ，搅拌速度为600 r/min；Span80 与Tween80 的质量比为2.5:1；异甘草素的加入量为30 mg。 得到微胶囊形态完好，表面光滑；平均包封率和载药量分别为 64.5%和4.24%。并在通过模拟肠液和模拟胃液中的释放曲线推测了其 释放机理。 关键词：异甘草素，微胶囊，体外释药性 文章篇号：1673-9078(2010)10-1132-1135[NO.] \* MERGEFORMAT Preparation of Isoliquiritigenin Microcapsule and their Release in Vitro 1 1 1,2 ZHOU Jin-xia , WU Lin , WANG Jian-guo (1.Applied Chemistry Research Institute Office of Wuhan University of Science and Technology, Wuhan 430081, China) (2.Jiujiang College of Chemistry and Chemical Engineering, Jiujiang 332005, China) Abstract: In this paper, isoliquiritigenin microcapsules were prepared and its release in vitro was also studied. The optimized conditions for the preparation of isoliquiritigenin microcapsules were sodium alginate concentration of 2%, stirring speed of 600r/min, the mass ratio of Span80 to Tween80 of 2.5:1 and isoliquiritigenin dosage of 30 mg. Under these conditions, the microcapsules had good shape and smooth surface, with the average encapsulation efficiency and drug loading being of 64.5% and 4.24%, respectively. And the release curves were made in simulated intestinal fluid and simulated gastric juice. Key words: isoliquiritigenin; microcapsules; in vitro release profile