一种中草药组方保健食品润肠通便功能的研究.pdf

现代食品科技 Modern Food Science and Technology 2016, Vol.32, No.1 一种中草药组方保健食品润肠通便功能的研究 金鑫，高擎，葛亚中 （无限极（中国）有限公司，广东广州 510640） 摘要：随着社会经济的发展和人们生活水平的提高，原有的饮食习惯逐步发生改变，便秘这一影响现代人生活质量的常见疾病 越来越受到重视，因此寻找安全有效的润肠通便产品显得十分重要。本文研究一种中草药组方保健食品的润肠通便功能。采用复方地 芬诺酯建立小鼠便秘模型，通过小鼠小肠推进实验和排便实验，检测小鼠的首次排便时间、5h 内排便粒数、排便重量、小肠墨汁推 进率，以及对小鼠结肠 P 物质（SP ）、血管活性肠肽（VIP ）和小鼠突触素（SY ）的影响。研究发现：与便秘模型组相比，中草药组 分保健食品各剂量组都能缩短复方地芬诺酯小鼠的排便时间，增加 5 小时小鼠排出的粪便粒数和重量，提高复方地芬诺酯小鼠的墨汁 推进率，促进小鼠的肠胃蠕动，提高小鼠的 SP 值，降低 VIP 值。结果表明，研究的中草药组方保健食品具有较好的润肠通便作用。 关键词：中草药；便秘；润肠通便；小鼠 文章篇号：1673-9078(2016)1-77-81 DOI: 10.13982/j.mfst.1673-9078.2016.1.012 Functional Action of a Chinese Herbal Compound in Improving Bowel Movement JIN Xin, GAO Qing, GE Ya-zhong (Infitinus (China) Co. Ltd., Guangzhou 510640, China) Abstract: With development of the social economy and improvement of people’s standard of living, traditional dietary habits have been gradually changing. Consequently, constipation, a common disease affecting quality of life, has attracted considerable attention. Therefore, it is very important to discover safe and effective products that can improve bowel movement. This study aims to evaluate the functional action of a Chinese herbal compound in improving bowel movement. A mouse model of constipation induced using diphenoxylate was used in small intestinal motility and bowel evacuation experiments. Measurements included the first evacuation time, the number of fecal pellets in five hours, the weight of evacuation, the movement rate of ink in the small intestine, and the effect of the herbal compound on colonic substance P (SP), vasoactive intestinal peptide (VIP), and synaptophysin (SY). The re