比较结核感染T细胞斑点试验、结核菌素试验以及血清结核抗体检测对诊断肺结核价值.doc

比较结核感染T细胞斑点试验、结核菌素试验以及血清结核抗体检测对诊断肺结核价值 　　[摘要] 目的 比较结核感染T细胞斑点试验（T-cell spot of tuberculosis，T-SPOT.TB）、结核菌素试验（purified protein derivative，PPD）以及血清结核抗体（Tuberculosis antibody，TB-Ab）?z测对肺结核的诊断价值。 方法 随机选取自2014年1月―2016年8月在该院确诊为肺结核患者60例，作为肺结核组；确诊非肺结核就诊者30名作为非肺结核组，两组就诊者均接受了T-SPOT.TB、PPD以及TB-Ab检测。比较两组接受不同检测方法对诊断肺结核灵敏性与特异性的差异。结果 T-SPOT.TB检测诊断肺结核的敏感性为73.30%，特异性为80.00%；PPD试验诊断肺结核的敏感性为60.00%，特异性为86.70%；血清TB-Ab检测检测诊断肺结核的敏感性为53.30%，特异性为66.70%。结论 T-SPOT.TB诊断肺结核的敏感性高于PPD试验和血清结核抗体检测；T细胞斑点试验T-SPOT.TB诊断肺结核的特异性高于血清结核抗体检测，与PPD试验差异无统计学意义 [关键词] 结核感染T细胞斑点试验；PPD试验；血清结核抗体；肺结核 [中图分类号] R322.3 [文献标识码] A [文章编号] 1674-0742（2016）12（b）-0041-03 Comparison of T-SPOT.TB， PPD， and TB-Ab Detection in the Diagnosis of Pulmonary Tuberculosis HUANG Han-peng Department of Respirology， Affiliated Hospital of Jiangsu University， Zhenjiang， Jiangsu Province，212001 China [Abstract] Objective To compare of T-cell spot of tuberculosis（T-SPOT.TB）， purified protein derivative test（PPD）， and serum tuberculosis antibody detection（TB-Ab） in the diagnosis of pulmonary tuberculosis. Methods 90 patients from January 2014 to August 2016 in our hospital were random selected and divided into pulmonary tuberculosis group（n=60） and non-tuberculosis group（n=30）. The positive rates of T-SPOT.TB， PPD， and TB-Ab in two groups were detected and their sensitivities and specifities were compared. Results The sensitivity of T-SPOT.TB in the diagnosis of pulmonary tuberculosis was 73.30%， and the specificity was 80.00%； The sensitivity of PPD test in the diagnosis of pulmonary tuberculosis was 60.00%， and the specificity was 86.70%； The sensitivity of TB-Ab detection in the diagnosis of pulmonary tuberculosis was 53.30% and specificity was 66.70%. Conclusion The sensitivity of T-SPOT.TB in the diagnosis of tuberculosis is higher than that of PPD test and TB-Ab detection； the specificity of T-SPOT.TB in diagnosis of pulmonary tuberculosis is higher than that of serum TB-Ab detection， and is no significant difference with