顺式阿曲库铵在新生儿腹腔镜下先天性巨结肠根治术中的应用.pdfVIP

·2074· 医学临床研究 2007年12月 第24卷 第12期 J Clin Res，Dec．2007，Vol 24，No12 · 论著· 顺式阿曲库铵在新生儿腹腔镜下先天性巨结肠根治术中 的应用 姜金玉 孔高茵 刘景诗 (湖南省人民医院，湖南 长沙 410005) [摘要]【目的】探讨顺式阿曲库铵(简称阿曲库铵)应用于新生儿的药效学特点。【方法】择期行腹腔镜下先 天性巨结肠根治术的新生儿6O例，于5 S内静注2ED9s(I组)或3ED9 (I1组)顺式阿曲库铵(n一30)，记录拇内收 肌肌颤搐高度并对插管条件进行评级。观察阻滞起效时间、TOF无反应期、阻滞维持时间、肌松恢复指数与体 内作用时间。【结果】Ⅱ组气管插管时肌松阻滞和插管条件较I组好。肌松起效时间Ⅱ组(90．5 s)较I组(145，5 s)短 (PO，01)。TOF无反应期、阻滞维持时间和体内作用时间两组比较均有显著性差异(P0．05)。两组肌松 恢复指数无显著差异(PO．05)。【结论】3ED9s诱导剂量应用于新生儿起效快且插管条件佳，且TOF无反应 期、阻滞维持时间和体内作用时间均较2 ED9s的时间长。两组恢复指数无明显差异。 [关键词] Hirschsprung病／外科学； 外科手术，腹腔镜； 阿曲库铵／治疗应用； 婴儿，新生，疾病 Application of Cisatracurium for Radical Operation on Congenital Megacolon Disease of New— born under Laparoscope JIANG Jin—yu， KONG Gao-yin， LIU jing—shi(Department of Anaesthesia，Hunan Provincial Peoples Hospital，Changsha 410005，China) I-A~traetq[Objective]To investigate the tracheal intubation conditions and pharrnacodynamics following the ad— ministration of different dosage of cisatracurium to newborn．[Methods]Sixty newborns undergoing elective laparo— scopic radical operation were randomized tO two groups(Group I and Group 1／)receiving 0．10 mg／kg(2ED~5)or 0． 15mg／kg(3ED9s)cisatracurium respectively(n一30)．Neuromuscular transmission was monitored by recording with Organon T0 Guard．Intubation conditions were assessed at T1=0 after cisatracurium administration by using a 4一 part scale．Onset time，nonreactive period of TOF，duration of action，recovery index，duration in vivo and hemody— namic responses were observed．[Results]The MAP and HR before and one minute after cisatracurium administra- tion had no significant deviation．The muscular blockage and intubation COnditions after 1 20 seconds were different be— tween two groups．Onset time in Group I1 was significantly shorter than that in Group I．Nonreactive period of TOF， duration of action and