黄芪配伍川芎嗪抗心肌缺血再灌注损伤的研究.pdfVIP

第7卷第6期 金华职业技术学院学报 DVo1．7 No．6 2007年l2月 ec．2007 黄芪配伍川芎嗪抗心肌缺血再灌注损伤的研究 宋丽华。汤碧娥 ，张宁， 陈晓明 (金华职业技术学院 生理学教研室，浙江 金华321007) 摘要：目的：观察黄芪注射液配伍川芎嗪对家兔心肌缺血再灌注损伤的保护作用。方法：采用在体家免冠状动脉阻 断的缺血／复灌损伤模型，测定心肌梗死面积、血浆中乳酸脱氢酶(LDH)和肌酸激酶(CK)活性及各项心室力学指标。结 果：与单纯缺血／复灌组相比，川芎嗪与黄芪两药明显降低心脏缺血／复灌后的梗死面积和血浆中LDH、CK含量，促 进左室收缩 (LVSP)、最大左室收缩速率(+dP／dt~和最大左室舒张速率(一dP／dt 的恢复，两药合用与单用比较各项 指标的恢复更加显著。结论：黄芪与川芎嗪两药合用在保护心肌缺血再灌注损伤中有显著的协同作用。 关键词：黄芪；川芎嗪；心肌；缺血／复灌 中图分类号：G285．5 文献标识码：A 文章编号：1671-3699(2007)06—0045—04 Study of Astragalus membranaceus Plus Ligustrazine in Protecting Myocardial Ischemia Reperfusion Injury SONG Li—hua，TANG Bi—e，ZHANG Ning，CHEN Xiao—ruing (Department ofPphysiology,Jinhua College ofProfession and Technology,Jinhua 321007，China) Abstract：Objective：To study the cardioprotection of Astragalus membranaceus plus Ligustrazine against myocardical ischemia／reperfusion injury．Methods：Rabbits hearts were subjected to 30 min of ischemia followed by 1 20 min reperfusion．The infarct size，lactate dehydrogenase(LDH)and creatine kinase activity (CK)and ventricular hemodynamic parameters were measured。Results：Myocardial infarct size was significantly smaller in rabbits pretreatment with Astragalus membranaceus plus Ligustrazine than in control rabbits．LDH and CK were lower in rabbits pretreatment with Astragalus membranaceus plus Ligustrazine than in control rabbits．Left ventricular systolic pressure (LVSP)and maximal velocity of contraction and relaxation (+dP／dtmax)were improved in rabbits pretreatment with Astragalus membranaceus plus Ligustrazine Compared with control I／R group．Conclusion：Astragalus membranaceus plus Ligustrazine could effectively protect