两种剂量辛伐他汀治疗高胆固醇血症对照观察.pdfVIP

辽 压 Li孝 亏院亏撮v2oo7 OcI．，28(5) J Liaon ingMed J aoning Med Universitv_… … 一 两种剂量辛伐他汀治疗高胆固醇血症对照观察 才树生 (锦西石化医院，辽宁葫芦岛125001) 【摘要】 目的 评价两种剂量的辛伐他汀治疗高胆固醇血症的疗效和安全性。方法 将77例高胆固醇血症患者随 机分为2组：辛伐他汀40mg／d组39例；辛伐他汀20mg／d组38例。随访8周，观察疗效和药物不良反应。结果 (1)辛 伐他汀40rag／d组和20mg／d组，治疗8周，均能显著降低血清胆固醇 (Tc)、甘油三酯 (TG)、低密度脂蛋白胆固醇 (LDL—C)、载脂蛋白B(APoB)水平 (P0、01)，升高高密度脂蛋白胆固醇 (HDL—C)、载脂蛋白A。(APoA。)水平 (P0．05)。(2)辛伐他汀40mg／d组与20mg／d组比较，降脂作用更明显，差异有显著性 (P0．05)，且按照中国《血脂 异常防治建议》标准，40mg／d组在治疗8周后总达标率、TC达标率、LDL—c达标率均显著优于20mg组 (P0．05)。且 40mg／d辛伐他汀未增加不良反应，与20mg／d组相似。结论 40mg／d辛伐他汀降脂疗效优于20mg／d，可提高血脂达标率， 且安全性相似，在治疗需要时可适时应用。 【关键词】 辛伐他汀；两种剂量；疗效和安全性 【中图分类号】 R541．4 【文献标识码】 A 【文章编号】 1000—5161(2007)05—0041—03 A Comparison Between the Efficacy and Safety of Two Doses of Simvastatin in Patients with Hypercholesteremia CAI Shu——sheng (Jinxi Petro—chemical Hospital，Huludao 125001 China) 【Abstract】 Objective To appraise the efficacy and safety of two different doses of Simvastatin in the treatment of hypercho1． esteremia、 Methods 77 patients of hypercholesteremia were separated into two groups at random．Observe the simvatatin groups of different doses(40mg／d，39 cases，20mg／d 38 eases)for 8 weeks about their efficacy and adverse reactions． ResuIts (1) Total cholesterol(TC)，triglycerin(TG)，low density lipoprotein thelesterol(LDL C)，apoprotein B(ApoB)were decreased(P 0．01)，while high density lipoprotein cholesterol(HDL—C)，apoprotein Al increased(P0．05)after the therapy in both groups．(2)The amplitudes change of these items was larger in group 40mg／d than in group 20mg／d(P0．05)．According to the standard of《prevention recommendation of Dyslipidemia))，percentage of patients that reached target TC and LDL—C was higher in group 40mg／d than in group 20mg／d(P0．05)．Adveme reac