TrkB及SliTrk5在膀胱癌中的表达.pdfVIP

目 录 中文摘要·············································································1 英文摘要·············································································3 英文缩写·············································································6 研究论文TrkB 及SliTrk5 在膀胱癌中的表达 前言·············································································7 材料与方法····································································9 结果·············································································12 附图·············································································15 附表·············································································16 讨论·············································································18 结论·············································································2 1 参考文献·······································································22 综述 膀胱癌的检测：基于尿液和血液标志物检测的评估 ··············24 致谢···················································································53 个人简历·············································································54 万方数据 中 文 摘 要 TrkB 及SliTrk5 在膀胱癌中的表达 摘 要 目的：膀胱癌是全世界最普遍的癌症之一，发病率正在逐年上升。膀 胱癌的发生机制非常复杂，尽管有大量研究，但有很多不明确的问题。但 如果及早检测到，膀胱癌治疗和应对会非常成功。因此，寻找膀胱癌相关 的分子，探讨作用机制，有助于我们丰富对膀胱癌的治疗和干预。 脑源性神经营养因子(BDNF)是神经营养素超家族一员，目前在神经 系统的病理生理学、心理学和神经病学的研究中，都体现出重要的功能。 最近，一些研究表明，脑源性神经营养因子及其受体TrkB 可能参与很多 恶性肿瘤的生长和转移，如神经母细胞瘤、前列腺癌、胰腺导管癌、肝细 胞癌和肺癌等。然而目前在膀胱癌中TrkB 是否激活尚不清楚。 Slit-和NTRK-like 家族（SliTrks ）的成员是1 型跨膜蛋白,这种蛋白在 中枢神经系统的突触中具有的本地化和功能化的作用，在这个系统中，它 们的胞外结构与突触前结合通过跨突触膜反应来调控突触的形成。Slitrk 蛋白家族被认为与神经精神障碍有关。其中SliTrk5 作为TrkB 的共受体，