167例2型糖尿病患者空腹血糖和胰岛素抵抗结果的分析.pdfVIP

现代中西医结合杂志Modern Journal of Integrated Traditional Chinese and Western Medicine 2008 Jan，17(2) ·177· 1 67例2型糖尿病患者空腹血糖和胰岛素 抵抗结果的分析 蔡文品，曾云祥，林高贵 (浙江省温州市第八人民医院，浙江温州325028) [摘要] 目的 观察2型糖尿病患者不同血糖水平的胰岛素抵抗和胰岛B细胞功能。方 法 167例患者分3组行1：／服葡萄糖耐量试验(oGTT)，检测血糖和胰岛素，按 HOMA模型计 算HOMA—IS、HOMA—IR。结果 当FPG大于7．0mmol／L时，空腹胰岛素开始下降，随FPG 的升高胰岛素抵抗和B细胞功能缺陷随之加重，组间比较P值均小于0．005。结论 在临床治 疗中按不同IR和 IS状况应采取不同措施严格控制血糖保护B细胞功能。 [关键词] 2型糖尿病；胰岛素抵抗；B细胞功能；葡萄糖毒性作用 [中图分类号]R587．1 [文献标识码]A [文章编号] 1008—8849(2008)02— 0177—02 Analysis of fasting blood glucose and insulin resistance in 167 cases of type 2 diabetes Cai Wenpin，Zeng Yunxiang，Lin Gaogui (The Eighth People’S Hospital of Wenzhou，Wenzhou 325028，Zhejiang，China) Abstract：Objective It is tO observe the insulin resistance and pancreatic islet B cell function in type 2 diabetes patients on different blood glucose leve1．Methods 167 patients were divided into three groups and received oral glucose tolerance tests． Glucose and insulin were examined．HOMA—IS and HOMA—IR were calculated according tO HOMA mode1．Results When FPG7．0 mmol／L，the concentration of insulin began tO decrease．Insulin resistance and B cell function defect were aggra- vated following FPG heighten，and there was significant difference among them(P0．005)．Conclusion During clinical therapy，different measure should have been taken tO control strictly blood glucose and tO protect B cell function according tO different IR and IS． Key words：type 2 diabetes；insulin resistance；B cell function；glucose toxic action 2型糖尿病是一种慢性进展性疾病，其发病的中心环节 7170A全自动生化分析仪上检测FBG、口服葡萄糖 1 h后血 是胰岛素抵抗和胰岛B细胞分泌功能缺陷。胰岛素抵抗贯穿