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乳腺癌患者手术前后血清S—CD105的表达及相关因素分析.pdf
· 952· 肿瘤防治研究2007年第34卷第12期
乳腺癌患者手术前后血清S—CD1 05的表达
及相关因素分析
张慧明,范忠林,马 力,高建茹
Expression and Correlation Factor Analysis of S-CD1 05 in Serum between Pre-and Post-
operation in Breast Can cer Patients
ZHANG Hui-ming,FAN Zhong-lin,MA Li,GAO Jian-ru
Department of Surgery,The Fourth Hospital of Hebei Medical University,Shijiazhuang 05001 1,
China
Corresponding Author:FAN Zhong-lin
Abstract:Objective To explore the expression and affective factors of S-CD1 05 in serum between pre-
and post-operation in breast cancer patients.Methods Serum level of S-CD1 05 was detected by ELISA
in 37 breast cancer patients.1 0 patients with breast benign tumor patients and 1 0 healthy adults.Results
Serum level of S-CD105 in breast cancer patients was obviously higher than that in patients with benign
tum or and healthy adults(P=0.021);serum level of S-CD1 05 in pre-operation patients was obviously
higher than that in post—operation patients(P=0.000).Further study found that serum level of S-CD1 05
risen up obviously in patients with the biggest diameter of tumor more than 5 cm,lymph node metastasis
more than 4,clinical TNM staging II or Ill stages and tissue with strongly positive expression of VEGF
(P0.05):the level in 1 patient with osseous metastasis risen up obviously.Conclusion The expression
0f SCD105 in serum rose up obviously in breast cancer patients,and it was positive correlated with tumor
size,axillary 1ym ph node metastasis,clinica1 TNM staging and the expression of VEGF in breast cancer
tissues,which indicates that S-CD1 05 has the clinical values in evaluation of prognosis.Serum level of S-
CD105 in 1 patient with osseous metastasis after operation rose up。which indicated that S-CD1 05 might
have the clinical value in monitoring the recurrence and metastasis,further study should be done.
Key wolds:Breast neoplasm;S-CD105;0peration;serum;Prognosis
摘 要:目的 探讨乳腺癌患者手术前、后血清S-CD105的表达情况及其影响因素。方法 用酶联免疫
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