非小细胞肺癌Stromal aminopeptidase N expression correlation with angiogenesis in non-small-cell lung cancer.pdfVIP

Gen Thorac Cardiovasc Surg (2009) 57:591–598 DOI 10.1007/s11748-009-0445-x ORIGINAL ARTICLE Stromal aminopeptidase N expression: correlation with angiogenesis in non-small-cell lung cancer Shinya Ito, MD, PhD · Ryo Miyahara, MD, PhD Rei Takahashi, MD, PhD · Shinjiro Nagai, MD, PhD Kazumasa Takenaka, MD, PhD Hiromi Wada, MD, PhD · Fumihiro Tanaka, MD, PhD Received: 26 December 2008 / Accepted: 6 April 2009 © The Japanese Association for Thoracic Surgery 2009 Abstract rates for APN-positive and APN-negative tumor stromal Purpose. Aminopeptidase-N (APN) is a membrane- cells were 66.0% and 69.8%, respectively, showing no bound protein that acts as a zinc-binding protease and difference in patient survival according to APN status participates in extracellular proteolysis. APN plays on the tumors’ stromal cells. important roles in tumor progression through promot- Conclusion. That APN expression on stromal cells was ing invasion and metastasis, prolonging survival of observed predominantly in squamous cell carcinoma tumor cells, and tumor angiogenesis. may account for the effi cacy of ubenimex in the postop- Methods. We evaluated APN expression in non-small- erative adjuvant setting for squamous cell carcinoma. cell lung cancer patients by immunohistochemistry. Results. Of the 95 patients reviewed in the present study, Key words Stroma · CD13 · Aminopeptidase-N · Non- 9 (9.5%), all with adenocarcinoma (Ad), showed positive small-cell lung cancer · Angiogenesis APN expression on the tumors’ cells. In all, 31 (32.6%) and 19 (20.0%) patients showed positive APN expression on the tumors’ stromal cells (fi broblasts) and microves- Introduction sels, respectively. APN expression on the tumors’ stromal cel