降脂通络软胶囊治疗酒精性脂肪肝（气滞血瘀证）的临床研究 - 神威药业.pdfVIP

·660 · Traditional Chinese Drug Research ＆ Clinical Pharmacology ，2010 November，Vol．2 1 No．6 · 临床研究· 降脂通络软胶囊治疗酒精性脂肪肝（气滞血瘀证）的临床研究 童文新，李振华，寇秋爱，尚晓泓（中国中医科学院西苑医院，北京 100091） 摘要：目的 研究降脂通络软胶囊对酒精性脂肪肝（气滞血瘀证）的临床疗效。方法 143例酒精性脂肪肝（气滞 血瘀证）患者随机分组，试验组72例，用降脂通络软胶囊治疗；对照组71例，用东宝肝泰片治疗，疗程均为8 周，比较两组患者治疗前后肝脾B超、中医证候、体征、血清生化指标、体重的变化。结果 试验组与对照组 中医证候总有效率分别为89.7 %、72.9 % ，组间比较差异有统计学意义（P 0.05）；试验组和对照组B超显示脂 肪肝严重程度改变的总有效率分别为57.4 % 、50.0 % ；试验组治疗后ALT、GGT有明显改善（P 0.05）；试验 组治疗后TC 、TG及LDL-C 降低，HDL-C升高（P 0.05），对照组治疗后TC 、HDL-C 降低（P 0.05）；B超显 示，试验组治疗后可显著减小患者左肝厚径和右肝斜径（P 0.05）；两组治疗后体重减轻（P 0.05）。结论 降脂通络软胶囊对脂肪肝气滞血瘀证有较好的临床疗效，明显改善酒精性脂肪肝（气滞血瘀证）患者的临床 症状，降低酒精性脂肪肝严重程度，减轻肝内脂肪含量，改善脂质代谢，保护肝功能，减轻患者的体重。 关键词：降脂通络软胶囊；酒精性脂肪肝；气滞血瘀证 中图分类号：R285.6 文献标识码：A 文章编号：1003-9783 （2010）06-0660-05 Clinical Study on the Treatment of Fatty Liver Disease （Qi Stagnation of and Blood-stasis） with Jiangzhi Tongluo Soft Capsules TONG Wenxin ，LI Zhenhua ，KOU Qiuai ，SHANG Xiaohong （Xiyuan Hospital of China Academy of Chinese Medi－ cal Sciences ，Beijing100091 ，China) Abstract Objective To observe the clinical curative effect of Jiangzhi Tongluo Soft Capsules （JTSC）for the treat－ ment of alcoholic fatty liver with the syndrome of Qi stagnation and blood-stasis ． Methods We selected 143 cases of alcoholic fatty liver patients which were divided into testing group and control group at random．Testing group had 72 cases and were treated with JTSC ，and the control group had 71 cases and were treated with Dongbao Gantai Tablets． The period of treatment of each group was 8 weeks．We compared the clinical manifestations ，the degree of seriousness reflected by B ultrasound examination ，the changes of serum biochemical indicators and body weight． Results （1） The overall clinical effective rate was 89.7% in testing group and 72.9 % in the control group ，the differences being significant between t