依伴侬用于子宫内膜异位症文献查阅总结.pdfVIP

皮下埋植剂依伴侬用于治疗子宫内膜 异位症文献汇总 1. Brief update on endometriosis treatment 该文章发表于2011 年，总结了子宫内膜异位症治疗最新进展，文章里提到，皮下埋植剂依 托孕烯可用作治疗子宫内膜异位症盆腔疼痛的另一选择，具有长期治疗子宫内膜异位症的 潜力。（Etonogestrel subdermal implants (Implanon) are an additional treatment option in women with symptoms related to pelvic endometriosis and has the potential for providing long-term treatment of endometriosis ） 2. The Effects of Implanon in the Symptomatic Treatment of Endometriosis 目的：评估依伴侬治疗子宫内膜异位症的有效性 设计：无对照组的开放性实验 方法及样本：共纳入50例有子宫内膜异位症症状的人群，通过腹腔镜诊断和确认，该样本群 的特点是经手术治疗后复发，植入依伴侬后，通过视觉模拟评分观察植入前、4周、12周患 者的疼痛强度，同时观察植入前、4周、12周的不良反映，以及对此类治疗方法的满意度。 结果 ：50名妇女全部完成了研究，植入前的痛经视觉模拟评分为7.08 ±2.09，4周为3.72 ± 2.09 ，12周为0.84 ±1.67。研究期间，正常月经、闭经、点滴出血、突破性出血的比率分别 是21(42%), 14(28%),13(26%), 及 2(4%) 。而在满意度方面，6(12%)非常满意，34 (68%) 满 意, 10(20%) 不确定，所有受试者在研究结束后仍持续使用依伴侬。 结论: 治疗子宫内膜异位症，皮下埋植依伴侬可作为一种额外的有效治疗方案，只是妇女在 植入前需要经过详细的咨询，了解其对月经模式的影响，可作为长期治疗子宫内膜异位症的 方案。但还需要更多的临床研究来比较不同治疗方案。 （Objective: To evaluate the efficacy of Implanon on treatment of symptomatic endometriosis Design: An open clinical study without control group Setting: Family Planning Clinic and out patient department, King Chulalongkorn Memorial Hospital, Bangkok, Thailand. Material and Method: A total number of 50 women with symptomatic endometriosis who were diagnosed and confirmed by laparoscopy or whose symptoms recurred after surgical treatment were recruited in the study . These subjects were implanted Implanon subcutaneously at medial aspect of non-dominant forearm. The intensity of pain was assessed with Visual Analog Scale (VAS) before insertion and at 4th and 12th weeks after the insertion. The adverse effects were recorded by the patients in 4th and 12th weeks of treatment. The women evaluated their satisfaction on treatment at the end of study. Result