药物化学实验与指导ExperimentalMedicinal.PDFVIP

药物化学实验与指导 Experimental Medicinal Chemistry 陈卫民 孙平华 金钱星 编著 王玉强 主审 暨南大学药学院 2006 年8 月28 日 目录(Contents) Section 1 Basic Knowledge Safety Practices in the Medicinal Chemistry Laboratory…………………………………………1 实验室安全知识………………………………………………………………………………….7 Section 2 Drug Synthesis Experiment 1 Synthesis of Phenytoin Sodium………………………………………………….14 实验一 苯妥英钠的合成……………………………………………………………………...17 Experiment 2 Synthesis of Aspirin……………………………………………………………...20 实验二 阿司匹林的合成…………………………………………………………………………23 Experiment 3 Synthesis of Procaine Hydrochloride…………………………………………….25 实验三 盐酸普鲁卡因的合成…………………………………………………………………..28 Experiment 4 Synthesis of Sodium Sulfabenzamide……………………………………………32 实验四 磺胺醋酰钠的合成………………………………………………………………………39 Experiment 5 Synthesis of Valproate Sodium…………………………………………………...43 实验五 丙戊酸钠的合成…………………………………………………………………………50 Experiment 6 Synthesis of Benzocaine………………………………………………………….54 实验六 苯佐卡因的合成………………………………………………………………………..61 Experiment 7 Synthesis of Norfloxacin…………………………………………………………65 实验七 氟哌酸的合成……………………………………………………………………………72 Section 3 Exercises of Medicinal Chemistry………………………………………………….80 The Answers……………………………………………………………………………………...120 Section 2 Drug Synthesis Experiment 1 Synthesis of Phenytoin Sodium Phenytoin sodium is an antiepileptic drug. It is still the drug of choice for the treatment of generalized tonic-clonic seizures (so-called grand mal epilepsy) and focal motor seizures. Nowadays, phenytoin has found new applications due to the n