四联液雾化吸入辅助治疗婴幼儿毛细支气管炎临床观察.docVIP

四联液雾化吸入辅助治疗婴幼儿毛细支气管炎临床观察【摘要】 目的 探讨干扰素、沙丁胺醇、丙酸培氢松、阿托品(四联液)雾化吸入辅助治疗婴幼儿毛细支气管炎的效果。方法 将180例毛细支气管炎患者随机分成治疗组和对照组各90例，两组均给予抗病毒、抗生素预防和治疗混合感染，治疗组加用四联液雾化吸入，对照组用α-糜旦白酶， 庆大霉素，地塞米松进行雾化吸入。结果 四联液组与对照组比较，疗效有高度显著性，且两组平均住院日、症状及肺部体征消失时间明显短于对照组。结论 四联液雾化吸入辅助治疗婴幼儿毛细支气管能明显改善症状，缩短病程，无严重不良反应。 【关键词】 四联液；雾化吸入；毛细支气管炎 Effects of inhalation therapy with four combined drugs used for the adnvat treatment of infant bronchiolitis CHEN Yanjiao Central Hospital of YiYang ,Hu Nan413000,China 【Abstract】 Objective To explore the effect of inhalation therapy with four combined drugs of interferon Salbulamol, Ipatropine and betamethasone on patients with infant bronchiolits. Method 180 were randomly assigned to treatmental and control group, all received anti-virus therapy preventive antibiotic administration, treatment for mixed infections. Patients in the treatmental group received inhalation therapy with four combined drugs, While subjects in the control group receive inhalation therapy with α-chymotrypsin, gentamicin and dexamethasone.Result Effect of inhalation on treatmental group was signifcantly better than in the control group .Length of hospital stay of the treatmental group was shorter than in the control group. The disappeared time of symptoms and pulmonary signs was markedly lower in the treatment group than in the control group.Conclusion Effect of inhalation therapy with four combined drugs can substointially improve the symptoms and shorten duration in the absence of severe adverse reactions. 【Key words】 Four combined drugs; Bronchiolitis; Inhalation 毛细支气管炎是婴幼儿特有的急性下呼吸道感染性疾病，主要为呼吸道合胞病毒感染所致，起病急骤，临床以咳嗽、喘憋、呼吸困难为主要症状，常致缺氧及多系统功能损害，不仅发病率高，死亡率亦高，严重影响患儿身体健康，目前无特效治疗方法。近年采用药物雾化吸入辅助治疗毛细支气管炎，取得显著疗效。现报告如下。 1 资料与方法 1．1 对象 将2002年5月至2006年3月入院的180例确诊为毛细支气管炎的婴幼儿随机分为治疗组和对照组，两组患者性别年龄情况如表1所示。 经统计处理两组年龄、性别无显著性差异，具有可比性。两组病例从发病到就诊时间平均为4．4 d，临床表现为咳嗽、喘憋、双肺闻及呼气性喘鸣音伴呼气延长，胸部X线示肺气肿及支气管周围炎影像、符合毛细支气管炎的临床诊断[１]。 1．2 方法 依毛细支气管炎治疗原则，在同时给予抗炎、抗毒、镇静、平喘、激素治疗的基础上实行不同的雾化吸入。用干扰素、沙丁胺醇、丙酸培氢松、阿托品四联液超声雾化吸入（以下简称