复方肾炎片联合贝那普利治疗慢性肾小球肾炎探究.docVIP

复方肾炎片联合贝那普利治疗慢性肾小球肾炎探究【摘要】 目的 观察复方肾炎片联合贝那普利治疗慢性肾炎蛋白尿的疗效。方法 将58例肾功能正常的慢性肾炎患者分为贝那普利 (ACEI组) 和复方肾炎片联合贝那普利组(联合组)，分别检测两组治疗前后24 h尿蛋白定量、血压、血肌酐。结果 治疗4个月后，联合组临床疗效总有效率（82.76％）显著高于贝那普利组（68.97％）(P＜0．05)，联合组的24 h尿蛋白低于ACEI组(P＜0．05)，血压、血肌酐两组差异无统计学意义（P＞0．05）。结论 复方肾炎片联合贝那普利比单用贝那普利能更有效地降低慢性肾炎患者蛋白尿，且安全可靠。? 【关键词】慢性肾炎；蛋白尿；复方肾炎片；贝那普利?? Clinical study of Fufang Shenyan pill combined with benazepril in treating chronic nephritis LIN Dan-hua，XU Hai-shan.Department of Nephrology，the Affiliated Hospital of Putian College,Putian City,Fujian Province 351100，China ? 【Abstract】 Objective To observe the clinical effect of Fufang Shenyan pill combined with benazepril in the treatment proteinuria of chronic nephritis. Methods 58 patiens were randomly divided into two groups: ACEI group in which 29 patiens were treated by benazepril and combined group in which 29 patiens were treated by Fufang Shenyan pill combined with Benazepril, with a course of 4 months. The clinical effect, 24-hour urinary protein, serum creatinine, blood pressure were observed. Results The total effective rate was 82.76% in combined group and 68.97% in ACEI group（P0.05）, 24-hour urinary protein of combined group was lower than of ACEI group（P0.05）. The differences of serum creatinine, blood pressure between the two groups were notsignificant. Conclusion Fufang Shenyan pill combined with benazepril is more effective in reducing proteinuria of chronic nephritis than individual benazepril.? 【Key words】Chronic nephritis; Urinary protein; Fufang Shenyan pill; Benazepril ? 慢性肾小球肾炎简称慢性肾炎，是肾科最常见的疾病之一，它是由多种病因引起的原发于肾小球的一组临床表现相似、病理改变不一、预后不尽相同的免疫性疾病。临床以蛋白尿或/和血尿、水肿、高血压，伴或不伴有肾功能不全为基本特征。蛋白尿是影响慢性肾炎预后的独立危险因素，降低蛋白尿是延缓肾功能衰竭的重要治疗措施之一。单用ACEI降低尿蛋白效果不佳。2007年11月至2008 年5月，笔者应用复方肾炎片联合贝那普利治疗肾功能正常的慢性肾炎蛋白尿，取得较为满意的疗效，现报告如下。? 1 资料与方法? 1．1 病例选择 所有患者均符合慢性肾小球肾炎诊断标准，具有以下特点①病史1年以上；②持续蛋白尿，尿蛋白1+～3+，24 h尿蛋白定量＜3.0 g，伴或不伴血尿；③伴有水肿或高血压之一；④血肌酐正常；⑤年龄在14岁以上，除外继发性或其他疾患以及妊娠或哺乳期妇女患者。? 1．2 分组及一般资料 58例患者来自专科门诊，分为两组，贝那普利组（ACEI组）和复方肾炎片联合贝那普利组（联合组）