1756例头孢他美酯干混悬剂使用研究.doc

1756例头孢他美酯干混悬剂使用研究[摘要] 目的：了解头孢他美酯干混悬剂在我院门诊儿科的使用情况。方法：随机抽查2006年1~12月门诊儿科头孢他美酯干混悬剂处方1 756份，根据该药的用法、用量、适应性、联合用药及处方诊断，分析头孢他美酯干混悬剂使用是否合理。结果：单一用药1 188例，占67.7%；二联用药564例，占32.1%；三联用药4例，占0.2%。联合抗菌药物构成为青霉素类348例，占61.3%；大环内酯类204例，占36.9%；其他抗菌药物16例，占2.8%。临床应用于急性上呼吸道感染、肠胃炎、扁桃体炎、咽炎、中耳炎、外伤预防感染。结论：头孢他美酯干混悬剂应用存在用药指征不明确、不恰当、不必要联合用药、选药档次过高等问题。 [关键词] 头孢他美酯干混悬剂；合理用药 [中图分类号]R969.3 [文献标识码]A [文章编号]1673-7210（2008）06（b）-119-02 Application analysis of Cefetamet Pivoxil Hydrochloride for Suspension in 1 756 cases ZENG Zhong-rong (The People′s Hospital of Beihai City, Beihai 536000,China) [Abstract] Objective: To investigate the problems of Cefetamet Pivoxil Hydrochloride for Suspension (CPHS) usd by pediatric outpatient.Methods:1 756 cases of pediatric outpatient using CPHS from January to December in 2006 were checked randomly. According to the usage, dosage, adaptability, combined medicament, the clinical application of CPHS was analyzed. Results: Single-drug 1 188 cases, consisted of 67.7%.Two-drugs 564 cases, 32.1%.Three-drugs 4 cases, 0.2%.The consist of antibiotics was penicillins 348 cases(61.3%), macrolides 204 cases(36.9%), other antibiotics 16 cases(2.8%). CPHS was used for upper respiratory tract infection, gastroenteritis, tonsillitis, pharyngitis, otitis media, injury infection prevention clinically. Conclusion: There are many problems in the application of CPHS, for example, without definite indications of medication, unsuitable and unnecessary drug combination, and too high grade of drugs. [Key words] Cefetamet Pivoxil Hydrochloride for Suspension; Rational drug use 头孢他美酯（CPH）为第三代广谱头孢菌素类药物，在体内被水解为有抗菌活性的头孢他美发挥作用，对链球菌属、肺炎链球菌等革兰阳性菌有抗菌作用；对大肠埃希菌、流感嗜血杆菌、克雷伯菌属、沙门菌属等革兰阴性菌有很强的抗菌活性，尤其对头孢菌素敏感性低的沙雷菌属、肠杆菌属、柠檬酸菌属的抗菌活性明显，对细菌产生的β-内酰胺酶稳定[1]。混悬剂易于分量、服用方便，被儿科广泛使用。本文对1 756例头孢他美酯干混悬剂（CPHS）处方进行分析，现报道如下： 1 资料与方法 1.1 资料来源 收集2006年1~12月儿科CPHS处方1 756份，详细填写调查表，其中，男性1 106例，年龄1~16岁；女性650例，年龄1~15岁。平均年龄8.5岁。 1.2 调查方法 采用回顾性调查方法，将抽取处方逐份查阅，记录患者的姓名、性别、年龄、诊断，CPHS的给药途径、剂量、联合用药，并进行