免疫增强剂、抗生素联合治疗儿童反复呼吸道感染临床观察.docVIP

免疫增强剂、抗生素联合治疗儿童反复呼吸道感染临床观察[摘要] 目的：观察免疫增强剂配合抗生素联合用于治疗儿童反复呼吸道感染的临床疗效。方法：反复呼吸道感染患儿105例，随机分为三组，丙种球蛋白组、胸腺肽组、对照组，各35例。对照组常规抗生素抗感染、对症治疗；丙种球蛋白组患儿除常规抗生素抗感染、对症治疗外，给予丙种球蛋白静脉滴注；胸腺肽组患儿在常规抗感染、对症治疗的基础上，加用胸腺肽治疗。结果：治疗后，丙种球蛋白组和胸腺肽组感染次数较治疗前明显减少（P＜0.05），感染持续时间较治疗前缩短非常显著（P＜0.01）。治疗后患儿的呼吸道感染次数，丙种球蛋白和胸腺肽组与对照组比较，差异有统计学意义（P＜0.05）；感染持续时间也明显短于对照组（P＜0.01）。治疗后丙种球蛋白和胸腺肽组与对照组间总有效率比较，有非常显著性差异（P＜0.01）。结论：在抗生素抗感染、对症治疗的基础上使用免疫增强剂（丙种球蛋白或胸腺肽），其疗效优于单纯抗生素。 [关键词] 反复呼吸道感染；免疫增强剂；抗生素；儿童 [中图分类号] R725.6[文献标识码]B [文章编号]1673-7210（2008）03（c）-059-02 A therapy of immunoenhancer combined with antibiotics to children repeatedly respiratory infection YANG Li-jun (Maternal and Child Health Hospital of Haizhu District of Guangzhou City,Guangzhou 510240,China) [Abstract] Objective: To observe the effect of antibiotics combined with immunoenhancer on children with repeatedly respiratory tract infection(RRTI). Methods:105 children with RRTI were randomly divided into three groups: gammaglobulin group, thymic peptide group and control group. The children in control group were treated with antibiotics; those in gammaglobulin group were used with gammaglobulin, those in thymic peptide group were treated with thymic peptide, combined with antibiotics. Results:The frequency and persistence time of RRTI in gammaglobulin and thymic peptide group were less than those in control group(P＜0.05, P＜0.01).Children in gammaglobulin and thymic peptide group got higher total effective rate than those in control group(P＜0.01).Conclusion:The effect of antibiotics combined with immunoenhancer on children with RRTI is better than antibiotics only . [Key words] Repeatedly respiratory tract infection; Immunoenhancer; Antibiotics; Children 反复呼吸道感染（RRTI）为儿科常见疾病，约占门诊病人的30%，它不仅影响患儿的生长发育和智力发育，也严重影响患儿的身心健康。因此，如何治疗小儿反复呼吸道感染是儿科医师必须面临的问题。儿童时期免疫功能随年龄增长逐渐完善，但抵抗各种病原体感染的能力尚不成熟，是部分小儿易患RRTI的重要原因之一，所以在抗生素抗感染治疗基础上，适当使用免疫增强剂改善患儿免疫功能，对防治小儿RRTI有一定作用。 1资料与方法 1.1一般资料 反复呼吸道感染患儿105例，其中，男56例，女49例，年龄1.5~6.5岁，平均3.7岁。病程（12.8±5.7）个月。所有病例均符合全国