孤独症儿童及其他精神障碍儿童围生期危险因素比较.docVIP

孤独症儿童及其他精神障碍儿童围生期危险因素比较【摘 要】目的:比较孤独症与其他精神障碍儿童围生期危险因素之间的差异。方法:应用自制围生期危险因素调查表对197例孤独症儿童和93例其他精神障碍儿童进行回顾性调查。应用t检验和卡方检验分析两组儿童之间围生期危险因素的差异。结果:孤独症组围生期危险因素发生率高于其他精神障碍组(68%vs.51%,P=0.003),其母孕期感冒史及早产史发生率均高于其他精神障碍组(14.2%vs.6.5%,10.7%vs.3.2%;P=0.038,0.022);两组儿童在喂养方式上差异也有统计学意义(孤独症组母乳喂养、混合喂养、人工喂养的比例分别为67.7%、15.0%、17.3%,其他精神障碍组3种喂养方式的比例分别为48.3%、22.4%、29.3%; P=0.038)。结论:母孕期感冒、早产和喂养方式与孤独症发病可能有某种联系。 【关键词】 孤独症;围生期;高危因素;回顾性研究 中图分类号:R749.94,R714.7 文献标识码:A 文章编号:1000-6729(2010)001-0025-04 doi:10.3969/j.issn.1000-6729.2010.01.006 Comparison of perinatal risk factors between patients with autism and other psychotic disorders HAO Xiao-Nan,ZHANG Dai,JIA Mei-Xiang Peking University Institute of Mental Health,Key Laboratory of Mental Health,Ministry of Health (Peking University),Beijing,China.100191 Corresponding author:ZHANG Dai,E-mail:daizhang@bjmu.省略 【Abstract】Objective:To explore the possible specific perinatal risk factors in the development of autism through comparing the perinatal risk factors between patients with autism and other psychotic disorders.Methods: In this retrospective research,197 cases with autism and 93 cases with other psychotic disorders were selected and assessed with the self-made scale of perinatal risk factors.Statistical analyses were performed using t test and Chi-square test.Results:Compared with the control group,the autistic subjects had a significantly higher frequency of the perinatal risk factors(51 % vs.68%,P=0.003),particularly the rate of catching a coldduring their mothers’ pregnancy(14.2% vs.6.5%,P=0.038)and the rate of prematurity(10.7% vs.3.2%,P=0.022)than the control subjects.Feeding methods was different between the two groups(P=0.038).Conclusion:Catching a cold during mothers’ pregnancy,prematurity and feeding methods may be related to the development of autism. 【Key words】 autism;perinatology;risk factor;retrospective research 孤独症(Autism)是一种广泛性发育障碍(pervasive development disorder,PDD),是儿童精神疾病中的一种严重精神障碍。近年来的研究报道其患病率