格列美脲联用金匮肾气丸治疗糖尿病临床疗效研究.docVIP

格列美脲联用金匮肾气丸治疗糖尿病临床疗效研究[摘要] 目的 探讨格列美脲联用金匮肾气丸治疗糖尿病的临床疗效分析。 方法 选择我院2011年2月～2012年2月2型糖尿病患者60例，将其随机分为观察组和对照组，每组各30例。对照组每日早晨服用格列美脲1 mg，并根据血糖控制情况可适当增加剂量；观察组在对照组基础上给予金匮肾气丸，每次6 g，每日3次，疗程为12周。比较两组疗效。 结果 观察组和对照组的总有效率分别为96.6%和73.3%，差异具有统计学意义（P 0.05）。对比两组的空腹血糖（FBG）、餐后2 h血糖（2 h PBG）、糖化血红蛋白HbAlc观察组降低效果更显著（P 0.05）。 结论 格列美脲与金匮肾气丸联用较单一使用格列美脲对于2型糖尿病具有更佳的治疗效果。 [关键词] 格列美脲；金匮肾气丸；糖尿病 [中图分类号] R587.1 [文献标识码] A [文章编号] 1673-7210（2012）07（c）-0110-02 Clinical analysis of Glimepiride combined with the Jingui Shenqi Pill in the treatment of diabetes GUO Yuting General Department, Space General Hospital, Beijing 100076, China [Abstract] Objective To collect summarize and analyze the clinical effects of Glimepiride and Jingui Shenqi Pill in the treatment of diabetes. Methods 60 patients with type 2 diabetes were selected in our hospital from February 2011 to February 2012, who were randomly divided into observation group and control group. The control group received Glimepiride 1 mg every morning and revised the dose according to blood glucose, the observation group received Jingui Shenqi Pill (6 g, tid.) 12 weeks of a course. The clinical effects were compared between the two groups. Results The effective rate of observation group and control group were 96.6% and 73.3% with statistically significance (P 0.05). while the level of FBG, 2 h PBG, HbAlc were reduced obviously in the observation group (P 0.05). Conclusion The treatment of type 2 diabetes with Glimepiride combined with Jingui Shenqi Pill has better effect than the single Glimepiride in the our study. [Key words] Glimepiride; Jingui Shenqi Pill; Diabetes 糖尿病是一种因胰岛素分泌绝对或相对不足，而引起来的以高血糖为主要特征的代谢疾病，长期的高血糖会导致眼、肾、神经、心脏及血管等多器官损害[1]。目前糖尿病的发病率在我国呈逐年上升的趋势，已成为继心脑血管疾病、恶性肿瘤之后的第三位人类杀手，已严重影响人们的身体健康，同时大多数患者对于血糖控制不尽如人意，有统计表明我国糖尿病患者血糖控制达标即糖化血红蛋白（HbA1c）6.5%者仅有11.5％[2]。2型糖尿病随着病程进展， 口服降糖药效果可能逐渐降低，从而发生继发性口服降糖药失效。因此，从天然药物中寻找合适的降糖药物是近年来科研工作者的研究重心。金匮肾气丸最早源自于汉代张仲景所著的《金匮要略》，由8味中药配伍组成，具有滋阴补肾的功效，适用于糖尿病及糖尿病相关病症以肾虚为主的患者，尤其是糖尿病晚期并发症为肾阳肾虚皆虚的患者[3-4]。格列美脲