药学-促胃肠动力药物探析（Pharmaceutical and gastrointestinal motility drugs）.docVIP

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药学-促胃肠动力药物探析（Pharmaceutical and gastrointestinal motility drugs）.doc

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药学-促胃肠动力药物探析（Pharmaceutical and gastrointestinal motility drugs）

药学-促胃肠动力药物探析（Pharmaceutical and gastrointestinal motility drugs） [Abstract] prokinetic drug therapy at home and abroad is more, FD study using drugs widely, is currently the major antibiotics in the treatment of functional dyspepsia, including dopamine receptor antagonist, peripheral dopamine receptor antagonist, 5- hydroxy tryptamine receptor preganglionic neurons (5-HT), and with dopamine stimulants D 2 receptor antagonist and inhibition of acetylcholinesterase activity in the dual role of new prokinetic agents. Several types of gastrointestinal motility drugs are mainly introduced in this paper. The [Key words] prokinetic agents; dopamine receptor antagonists; itopride 1 the dopamine receptor antagonist The gastrointestinal tract have more expression of dopamine receptors, dopamine can reduce the pressure of the stomach and esophageal sphincter rhythm, coordination effect of gastric and duodenal motility, effects of dopamine on these effects is through the activation of dopamine receptors, but also some scholars believe that acts via the adrenergic receptor, the scholars further through living animal research think through the gastrointestinal tract of the dopaminergic receptor (such as activation of central dopamine receptor) to affect gastrointestinal motility. The The main representative drugs including metoclopramide (trade name: metoclopramide, domperidone and metoclopramide) (trade name: Ding Lin). Metoclopramide is the first synthetic gastrointestinal motility drug in the 1964 and is the central and peripheral dopamine receptor antagonist. Domperidone is at the end of 1990s the first peripheral dopamine receptor antagonist, not easily through the blood-brain barrier, less adverse reactions in the central nervous system, to avoid the adverse reactions of central metoclopramide. Metoclopramide and domperidone on dopamine Dz receptor to block the inhibitory effect of dopamine on the smooth muscle of the digestive tract, especially for proximal gastrointestina