终稿来曲唑与克罗米芬促排卵治疗pcos科研研究(李媛修改后)41.docxVIP

来曲唑与克罗米芬对多囊卵巢综合征患者促排卵治疗结局的前瞻性随机对照研究*朱华牛爱菊**（山东省桓台县妇幼保健院,桓台256400）摘要目的：比较来曲唑和克罗米芬对多囊卵巢综合征患者（PCOS）促排卵治疗的效果和妊娠结局。方法：选取拟行促排卵治疗的PCOS患者136例，随机分为来曲唑组(LE)68例和克罗米芬组(CC)68例。HCG注射日观察平均直径14-18mm的卵泡数、平均直径≥18mm的卵泡数、子宫内膜厚度和血清E2水平；比较两组HMG用量、促排卵时间、排卵率、临床妊娠率、流产率、畸形率及卵巢过度刺激综合征（OHSS）的发生率。结果：LE组HCG日注射日平均直径14-18mm卵泡数、E2水平显著低于CC组，子宫内膜厚度及单卵泡排卵率显著高于CC组（P0.05）；LE组HCG日注射日平均直径≥18 mm卵泡数略低于CC组，但差异不显著（P0.05）；CC组OHSS发生率为7.4%，LE组无OHSS发生，两组相比差异有统计学意义（P0.05）；LE组临床妊娠率略高于CC组，但差异无统计学意义（P0.05）。结论：来曲唑用于治疗多囊卵巢综合征引起的无排卵性不孕，单卵泡排卵率和临床妊娠率良好，临床应用前景较好，有可能成为新一代一线促排卵药物。关键词来曲唑；克罗米芬；PCOS；促排卵中图分类号：R977.1+5Prospective research on the results of letrozole and clomiphene citrate for ovulation induction in PCOSpatients.Zhu Hua,Niu Aiju *.Shandong Huantai Maternal and Child Health Hospital,Huantai 256400Abstract Objective:To compare the effects of ovulation and pregnancy outcomesof letrozole and clomiphene citrate in the patients with polycystic ovarian syndrome (PCOS).Method:The 136 PCOS patients who performed oocyte induction were divided into two groups randomly, the letrozole group (LE, 68 cases) and the clomiphene citrate group (CC, 68 cases).The number of follicles 14-18mm in diameter, the average number of follicles ≥ 18mm in diameter, endometrial thickness and serum E2 levels were compared on the day of HCG injection.The HMG dosage, duration of ovulation, ovulation rate, clinical pregnancy rate, abortion rate, malformation rate and ovarian hyperstimulation syndrome (OHSS) incidence were also compared. Results:The number of follicles 14-18mm in diameter and E2 levels was significantly lower in LE group than that in CC group (P0.05).The endometrial thickness and single follicle ovulation rate were significantly higher in LE group than thatin CC group.The number of follicles ≥ 18 mm diameter in LE group was slightly lower than the CC group. OHSS incidencein CC group was 7.4%, but there was no OHSS in LE group (P0.05). The pregnancy rate in LE group was a little higher than the CC group, but not significant (P0.05)