儿童肝脏恶性肿瘤52例分析.pdfVIP

里 撮 ) 复 琴 (医学版 Fudan Univ J Med Sci 2。。8 Jan,35uu0 L l(1) 133 an Univ Sc 儿童肝脏恶性肿瘤52例分析 王中林 王晓红 王岱明 (复旦大学附属儿科医院感染科肝病中心 上海 200032) 【摘要】 目的 研究儿童肝脏恶性肿瘤的临床特点。方法 回顾性分析1990~2005年期间收住我院诊断为肝 脏恶性肿瘤的52例患儿临床和病理。结果 52例中男：女2．7：1。分类以肝母细胞瘤为主(29／52)，其次为肝 细胞肝癌(I2／52)。肝母细胞瘤较多发生在小年龄儿童，29例肝母细胞瘤中24例(82．8 )6岁，而 I2例肝细 胞癌中5例(41．7 )6岁。HBsAg阳性在肝细胞癌多见，12例肝细胞癌中5例 HBsAg标记阳性，29例肝母 细胞瘤中仅2例阳性，两者差别有统计学意义(P=0．03)。本组肝肿瘤患儿临床表现大多为腹块、腹胀或腹痛。 常见体征有肝肿大、脾肿大等。B超和CT等影像学检查示右肝叶病变为多。甲胎蛋白阳性71．4 。结论 儿 童肝脏恶性肿瘤多见于男孩，以肝母细胞瘤为多；肝细胞癌患儿乙肝病毒携带率高于肝母细胞瘤，显示乙肝病 毒与肝细胞癌关系密切。 【关键词】 肝母细胞瘤； 肝细胞癌； 儿童 【中图分类号】 R 735．7 【文献标识码】 B Malignant liver tumor in children and 52 cases reported WANG Zhong—lin，WANG Xiao—hongA，WANG Dai—ming (Department of Infectious Diseases and Center of Liver Diseases，Children’S Hospital， Fudan University，Shanghai 200032，China) [Abstract] Objective To investigate clinical characteristics of malignant liver tumor in children． Methods A retrospective study was conducted in 52 cases of chidren with malignant liver tumor be— tween 1990 and 2005．Clinical features and pathological results of all patients were analyzed． Results Ratio of male to female was 2．7：1(38：14)．Of the 52 cases。29 were diagnosed as hepato— blastoma，1 2 were hepatocelluar carcinoma．Hepatoblastoma was more often than hepatocelluar carci— noma in younger chidren．82．8 percent of hepatoblastoma(24／29)and 41．7 percent of hepatocelluar carcinoma(5／12)were younger than 6 years old(P=0．01)．The prevalence of HBsAg was higher for hepatocelluar carcinoma(41．7 )than that of hepatoblastoma(6．9 )with statistical significant difference(P=0．03)．Asymptomatic abdominal mass，abdominal pain and he