兔VX2肝癌模型制作方法改进及影像学评价.pdfVIP

中国医学影像技术2008年第24卷第2期 Chin J Med Imaging Technol，2008，Vol 24，No 2 · 185· ◆：◆实验研究 Improvement of VX2 liver tumor in rabbits and its image evaluation XI Zhan-guo ，SUN Ju-bao ，CHEN Mei ，WANG Hong-yan。，CHEN Dian-sen ， LJ Xing-mei 。YANG Hai—xia 。XINGLwqi (1．Department of Ultrasound，2．Room of MRI，3．Department of Oncology，4．Room of CT， 5．Center of PET，6．Department of Pathology，the First Af liated Hospital， Henan University of Science and Technology，Luoyang 471003，China) [Abstract] Objective To improve the creation of rabbit model bearing VX2 liver tumor，compare the imaging performance of ultrasound．CT and MRI in rabbit bearing VX2 liver tumor．Methods VX2 tumor was implanted in 60 Japan white rab- bits by four methods：laparotomic puncture，laparotomic burying，18G needle and 16G needle puncture under ultrasound guidance percutaneously，1 5 rabbits per group．Two weeks after inoculating，tumor growth was monitored by ultrasound， CT and MRI．Results The success rate of original neoplasia was significantly higher in the group A，B and D compared with group C．The ectopic implantation rate was significantly higher in the group A and B compared with group D．Ultrasound showed that the tumor in the rabbit liver was spherical or sphere-alike hypoeehoie nodule，and there were blood flow signals in and around the nodle．VX2 tumor in the liver appeared as a solitary lOW density nodle on unenhanced CT scanning．On MR scanning，the VX2 liver tumors were seen as hyperintensity on T1WI and slight hyperintensity on T2WI．Conclusion The establishment of model by 16G needle puncture under ultrasound guidance percutaneously was easier，success rate highly and single node．The image manifestations of the VX2 tumor in rabbits