内置式山羊下颌骨二维牵张器实验探究.doc

内置式山羊下颌骨二维牵张器实验探究[摘要]目的：探讨用自行研制的内置式二维牵张器在山羊下颌骨上进行二维牵张的可能性。方法：进行离体实验预牵张；建立山羊下颌骨二维牵张的动物模型，牵引过程中拍摄X线片以监测牵张进度和牵张间隙内成骨情况，牵张结束后和固定8周后进行HE染色做组织学观察。结果：离体实验可以完成整个牵张过程；4只山羊成功建立下颌骨二维牵张动物模型，牵张间隙内新骨形成确切，X线片和组织学切片均显示固定8周后新生骨已经接近正常骨质。结论：自行设计的内置式山羊下颌骨二维牵张器可以完成山羊下颌骨的二维牵张成骨并可能具有一定的临床应用价值。 [关键词]牵张成骨；二维牵张器；下颌骨 [中图分类号]R782.2 [文献标识码]A [文章编号]1008-6455（2009）03-0310-03 An experiment of a novel internal two-dimensional distractor for mandible elongation on goat LIN Xiao-zhen,SHANG Hong-tao,ZHAO Jin-long,HE Li-sheng,BO Bin,LIU Yan-pu （Department of Oral and Maxillofacial Surgery,School of Stomatology,the Fourth Military Medical University,Xi’an 710032,Shaanxi,China） Abstract: Objective To discuss the feasibility of two-dimensional distraction osteogenesis of mandible of goat by using a novel distractor invented by us. Methods An experiment in vitro was made at first. Animal models of two-dimension distraction osteogenesis were established afterwards on four goats, all the goats were X-rayed during the active distraction phase and consolidation phase, and historical sections were made at the end of active distraction and the end of 8-week consolidation. Results Distraction could be carried out in vitro; all the four goats were established animal models of two-dimensional distraction osteogenesis of mandible successfully and the newly-formed bone was restored in the distracted area, radiographs and historical sections both showed that the newly-formed bone tissue was similar to normal bone after 8 weeks of consolidation. Conclusions the novel distractor is eligible to complete two-dimensional distraction osteogenesis of mandible on goat and may have a prospect in clinical application. Key words：distraction osteogenesis;two-dimension distractor; mandible 颞颌关节强直伴发的下颌骨畸形往往需要同时延长下颌骨升支和体部，但是目前应用于下颌骨的牵张器大多是直线式，因此笔者设计了一种内置式的下颌骨二维牵张器，希望可以同时牵张下颌骨升支和体部并成骨，从而应用于颞颌关节强直伴发的下颌骨畸形的临床治疗，然而任何一种新技术在临床的推广应用都离不开前期的基础研究, 其中动物模型的建立尤为重要，本研究选用山羊作为建模对象, 探讨用自行研制的内置式下颌骨二维牵张器的进行下颌骨二维牵张成骨的可能性。