布替萘芬联合硼酸治疗浸渍糜烂型足癣疗效观察.docVIP

布替萘芬联合硼酸治疗浸渍糜烂型足癣疗效观察摘 要 目的：观察1%盐酸布替萘芬乳膏联合3%硼酸液治疗浸渍糜烂型足癣的疗效。方法：浸渍糜烂型足癣患者104例，随机分成两组，治疗组56例，先用3%硼酸浸泡患处，20分钟/次，2次/日，每次浸泡后均晾干后局部外用1%盐酸布替萘芬乳膏，疗程2周；对照组48例，仅局部外用1%盐酸布替萘芬乳膏，2次/日，疗程2周。结果：治疗组治愈率67.9%，有效率96.4%，真菌清除率94.6%；对照组治愈率52.1%，有效率85.4%，真菌清除率83.3%。两组临床疗效及真菌学疗效比较，差异均具有显著性意义(X2=6.24，P0.05；X2=4.16,P0.05)。结论：1%盐酸布替萘芬乳膏联合3%硼酸液治疗浸渍糜烂型足癣，起效快、疗程短、疗效好。 关键词 布替萘芬乳膏 3%硼酸 足癣?治疗 doi:10.3969/j.issn.1007-614x.2009.11.042? AbstractPurpose:to observe curative effect of 1% hydrochloric acid Butenafine emulsifiable paste combined with 3% boric acid liquid on the pickling erosion tinea pedis.Method:104 pickling erosion tinea pedis patients were divide into two groups randomly.Firstly use 3% boric acid to soak affected part for 56 cases in the treatment group,20 minutes/time,2 times/day,after soaking every time and airing water content,locally externally using 1% hydrochloric acid Butenafine emulsifiable paste,with treatment period of 2 weeks。Result： treatment group:curative ratio 67.9%,effective rate 96.4%,hysterophyta clearance rate 94.6%;Control Group:curative ratio 52.1%，effective rate 85.4%,hysterophyta clearance rate 83.3%.By contrast for clinic curative effect and mycology curative effect in two groups,difference has distinctive ignificance(X2=6.24,P0.05；X2=4.16，P0.05).Conclusion:When 1% hydrochloric acid Butenafine emulsifiable paste combined by 3% boric acid liquid is used for treatment of pickling erosion tinea pedis,it is fast in onset,short in period of treatment and good in curative effect. Keyword Butenafine emulsifiable paste;3% Boric acid;Tinea pedis;Treatment? 足癣是皮肤癣菌侵犯足部皮肤所引起的浅部真菌感染性疾病，俗称“脚气”，临床分为水疱型、角化过度型、浸渍糜烂型三型。该病的治疗方法很多，但疗效不甚理想，尤其是浸渍糜烂型足癣常伴有足部多汗、浸渍、糜烂、恶臭等表现，病情易反复，临床上缺乏有效的治疗方法。2007年4～9月，我科应用1%盐酸布替萘芬乳膏联合3%硼酸液治疗浸渍糜烂型足癣取得满意疗效，现报告如下。 资料与方法 一般资料：以典型皮损并真菌直接镜检阳性的门诊确诊患者104例，年龄14～65岁，平均39岁。随机分成治疗组和对照组。治疗组56例，男36例，女20例，病程8个月～5年；农业人口38例(66%)，城镇人口18例(34%)。对照组48例，男30例，女18例，病程10个月～5年，农业人口33例(69%)，城镇人口15例(31%)。两组患者在性别、年龄、病程及临床表现上无明显差异，具有可比性。所有患者无本研究用药禁忌证，近1个月内无口服及(或