expression of il-17, il-23 and their receptors in minor salivary glands of patients with primary sj？grens syndrome表达il-17,il-23及其受体在小唾液腺的患者主要sj gren综合征.pdfVIP

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expression of il-17, il-23 and their receptors in minor salivary glands of patients with primary sj？grens syndrome表达il-17,il-23及其受体在小唾液腺的患者主要sj gren综合征.pdf

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expression of il-17, il-23 and their receptors in minor salivary glands of patients with primary sj？grens syndrome表达il-17,il-23及其受体在小唾液腺的患者主要sj gren综合征

Hindawi Publishing Corporation Clinical and Developmental Immunology Volume 2012, Article ID 187258, 8 pages doi:10.1155/2012/187258 Research Article Expression of IL-17, IL-23 and Their Receptors in Minor Salivary ¨ Glands of Patients with Primary Sjogren’s Syndrome Diana Mieliauskaite, Irena Dumalakiene, Rita Rugiene, and Zygmunt Mackiewicz Department of Experimental and Clinical Medicine, State Research Institute Center for Innovative Medicine, Zygimantu Street 9, 01102 Vilnius, Lithuania Correspondence should be addressed to Diana Mieliauskaite, diana.mieliauskaite@ekmi.vu.lt Received 30 June 2011; Revised 28 September 2011; Accepted 28 September 2011 Academic Editor: Peter Szodoray Copyright © 2012 Diana Mieliauskaite et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The main purpose of this study was to determine the expression of interleukins-17/-23 (ILs-17/-23) and receptors of interleu- ¨ kins-17/-23 (IL-17R, IL-23R) in minor salivary glands (MSGs) of patients with primary Sjogren’s syndrome (pSS). Expression of IL-17, IL-23 and receptors of IL-17/-23 was analyzed in MSGs from 25 patients with pSS, 25 patients with probable preclinical pSS, and 25 patients with nonautoimmune sicca syndrome by immunohistochemistry. Comparison of the expression of IL-17, IL-23 and receptors of IL-17, IL-23 in MSG of patients with pSS with probable preclinical pSS, and with nonautoimmune sicca syndrome showed signiﬁcant diﬀerences between th