epigenetic regulation of b lymphocyte differentiation, transdifferentiation, and reprogramming表观遗传调节b淋巴细胞分化,分化转移和重组.pdfVIP

Hindawi Publishing Corporation Comparative and Functional Genomics Volume 2012, Article ID 564381, 10 pages doi:10.1155/2012/564381 Review Article Epigenetic Regulation of B Lymphocyte Differentiation, Transdifferentiation, and Reprogramming Bruna Barneda-Zahonero,1 Lidia Roman-Gonzalez,1 Olga Collazo,1 Tokameh Mahmoudi,2 and Maribel Parra1 1 Cellular Diff erentiation Group, Cancer Epigenetics and Biology Program (PEBC), Bellvitge Biomedical Research Institute (IDIBELL), Avenida Gran Via s/n km 2.7, 08907 L’Hospitalet de Llobregat, Barcelona, Spain 2 Department of Biochemistry, Erasmus University Medical Center, Ee622, P.O.Box 2040, 3000 CA Rotterdam, The Netherlands Correspondence should be addressed to Maribel Parra, mparra@idibell.cat Received 7 February 2012; Revised 21 May 2012; Accepted 6 July 2012 Academic Editor: Sonia Vanina Forcales Copyright © 2012 Bruna Barneda-Zahonero et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. B cell development is a multistep process that is tightly regulated at the transcriptional level. In recent years, investigators have shed light on the transcription factor networks involved in all the differentiation steps comprising B lymphopoiesis. The interplay between transcription factors and the epigenetic machinery involved in establishing the correct genomic landscape characteristic of each cellular state is beginning to be dissected. The participation of “epigenetic regulator-transcription factor” complexes is also crucial for directing cells during reprogramming into pluripotency or lineage conversion. In this context, greater knowled