circulating endothelial microparticles in diabetes mellitus循环内皮微粒在糖尿病.pdfVIP

Hindawi Publishing Corporation Mediators of Inflammation Volume 2010, Article ID 250476, 8 pages doi:10.1155/2010/250476 Clinical Study Circulating Endothelial Microparticles in Diabetes Mellitus A. F. Tramontano,1 R. Lyubarova,2 J. Tsiakos,3 T. Palaia,4 J. R. DeLeon,3 and L. Ragolia4 1 Division of Cardiology, Fletcher Allen Health Care and the University of Vermont School of Medicine, Burlington, VT 05401, USA 2 Division of Cardiology, Department of Medicine, Albany Medical Center, Albany, NY 12208, USA 3 Division of Cardiology, Stony Brook University School of Medicine at Winthrop-University Hospital, Mineola, NY 11501, USA 4 Vascular Biology Institute, Stony Brook University School of Medicine at Winthrop-University Hospital, Mineola, NY 11501, USA Correspondence should be addressed to A. F. Tramontano, antoniotramontano@ Received 22 December 2009; Accepted 18 March 2010 Academic Editor: Rhian Touyz Copyright © 2010 A. F. Tramontano et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Background. Endothelial Microparticles (EMPs) are small vesicles shed from activated or apoptotic endothelial cells and involved in cellular cross-talk. Whether EMP immunophenotypes vary according to stimulus in Diabetes Mellitus (DM) is not known. We studied the cellular adhesion molecule (CAM) profile of circulating EMPs in patients with and without Diabetes Mellitus type 2, who were undergoing elective cardiac catheterization. Methods and Results. EMPs were analyzed by flow cytometry. The absolute median number of EMPs (EMPs/μL) specific for CD31, CD105, and CD106 was significantly increased in the DM population