encapsulation of diclofenac molecules into poly(-caprolactone) electrospun fibers for delivery protection双氯芬酸分子的封装成聚己内酯)实际上电纺纤维提供保护.pdfVIP

Hindawi Publishing Corporation Journal of Nanomaterials Volume 2009, Article ID 238206, 8 pages doi:10.1155/2009/238206 Research Article Encapsulation of Diclofenac Molecules into Poly(ε-Caprolactone) Electrospun Fibers for Delivery Protection Loredana Tammaro, Giuseppina Russo, and Vittoria Vittoria Department of Chemical and Food Engineering, University of Salerno, Via Ponte Don Melillo, 84084 Fisciano, Italy Correspondence should be addressed to Vittoria Vittoria, vvittoria@unisa.it Received 16 June 2009; Accepted 22 September 2009 Recommended by David Hui Mg-Al Hydrotalcite-like clay (LDH) intercalated with diclofenac anions (HTlc-DIC) was introduced into poly(ε-caprolactone) (PCL) in different concentrations by the electrospinning technique, and mats of nonwoven fibers were obtained and compared to the pristine pure electrospun PCL. The fibers, characterized by X-ray diffraction, thermogravimetric analysis, and differential scanning calorimetry, show an exfoliated clay structure up to 3 wt%, a good thermal stability of the diclofenac molecules and a crystallinity of PCL comparable to the pure polymer. The scanning electron microscopy revealed electrospun PCL and PCL composite fibers diameters ranging between 500 nm to 3.0 μm and a generally uniform thickness along the fibers. As the results suggested the in vitro drug release from the composite fibers is remarkably slower than the release from the corresponding control spun solutions of PCL and diclofenac sodium salt. Thus, HTlc-DIC/PCL fibrous membranes can be used as an antinflammatory scaffold for tissue engineering. Copyright © 2009 Loredana Tammaro et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium,