原创力文档behaviour and degenerative changes in the basal forebrain systems of aged rats (12 months old) after levo-acetyl-carnitine treatments行为和老龄大鼠基底前脑系统的退行性变化levo-acetyl-carnitine治疗后(12个月).pdfVIP
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behaviour and degenerative changes in the basal forebrain systems of aged rats (12 months old) after levo-acetyl-carnitine treatments行为和老龄大鼠基底前脑系统的退行性变化levo-acetyl-carnitine治疗后(12个月)
Journal of Behavioral and Brain Science, 2012, 2, 18-25
/10.4236/jbbs.2012.21003 Published Online February 2012 (http://www.SciRP.org/journal/jbbs)
Behaviour and Degenerative Changes in the Basal
Forebrain Systems of Aged Rats (12 Months Old) after
Levo-Acetyl-Carnitine Treatments
1,2 1 1 1*
Roberta Freddi , Piergiorgio Duca , Maurizio Mariotti , Ivana Gritti
1Department of Clinical Science-Luigi Sacco, School of Medicine and Surgery, University of Milan, Milano, Italy
2Complex Structure-Anatomia Patologica, A.S.L.-VCO, Verbania, Italy
*
Email: Ivana.Grittti@unimi.it
Received June 30, 2011; revised November 22, 2011; accepted December 7, 2011
ABSTRACT
One group of six male control rats [12 months old] and one group of six male rats of the same age, singularly main-
tained in a cage, and treated with acetyl-L-carnitine-HCl [(gamma-trimethyl-beta-acetyl-butyrobetaine-HCl: Sigma-Tau
code ST200 or ALCAR: 60 mg/kg/day[7]/po)] for six months were tested in the spatial learning/memory Morris maze-
water task and for atrophy and cell loss in seven myelo- and cytostructurally defined basal forebrain (BF) cholinergic
regions [Freddi et al., 2009]. Coronal sections 25 μm thick were cut through the BF regions and processed every 200
μm for choline acetyltransferase (ChAT) immunohistochemistry. The ALCAR-treated rats had significantly shorter exit
times on the Morris maze-water task test than the control rats (average ± SD 28.3 ± 12.4 s vs. 61.16 ± 4.67 s; t = 6.07,
DOF = 10, P = 0.0001). Degenerative morphological changes in the BF ChAT-positive cells were observed in the sub-
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