biodistribution of 60co–cographitic-shell nanocrystals in vivobiodistribution 60 co-cographitic-shell体内纳米晶体.pdfVIP

Hindawi Publishing Corporation Journal of Nanomaterials Volume 2011, Article ID 842613, 5 pages doi:10.1155/2011/842613 Research Article Biodistribution of 60Co–Co/Graphitic-Shell Nanocrystals In Vivo Li Zhan,1 Qi Wei,1 Geng Yanxia,1 Xu Junzheng,1 and Wu Wangsuo1, 2 1 Radiochemistry Laboratory, School of Nuclera Science and Technology, Lanzhou University, Lanzhou 73000, China 2 State Key Laboratory of Applied Organic Chemistry, Lanzhou University, Lanzhou 730000, China Correspondence should be addressed to Wu Wangsuo, wuws@ Received 21 February 2011; Revised 12 April 2011; Accepted 23 May 2011 Academic Editor: Xing J. Liang Copyright © 2011 Li Zhan et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The magnetic nano-materials, Co/graphitic carbon- (GC-) shell nanocrystals, were made via chemicalvapour deposition (CVD) method, and their biodistribution and excretion in mice were studied by using postintravenously (i.v.) injecting with 60 Co–Co/GC nanocrystals. The results showed that about 5% of Co was embedded into graphitic carbon to form multilayer Co/GC nanocrystals and the size of the particle was ∼20 nm, the thickness of the nanocrystal cover layer was ∼4 nm, and the core size of Co was ∼14 nm. Most of the nanocrystals were accumulated in lung, liver, and spleen after 6, 12, 18, and 24 h after i.v. with 60 Co–Co/GC nanocrystals. The nanoparticles were cleared rapidly from blood and closed to lower level in 10 min after injection. The 60 Co– Co/GC nanocrystals were eliminated slowly from body in 24 h after injection, ∼6.09% of 60 Co–Co/GC nanocrystals were excreted by urine, ∼1.85% by feces in 24 h