bioengineering functional copolymers. xvii. interaction of organoboron amide-ester branched derivatives of poly(acrylic acid) with cancer cells生物工程功能的共聚物。.pdfVIP

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bioengineering functional copolymers. xvii. interaction of organoboron amide-ester branched derivatives of poly(acrylic acid) with cancer cells生物工程功能的共聚物。.pdf

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bioengineering functional copolymers. xvii. interaction of organoboron amide-ester branched derivatives of poly(acrylic acid) with cancer cells生物工程功能的共聚物。

Journal of Cancer Therapy, 2011, 2, 266-275 doi:10.4236/jct.2011.22034 Published Online June 2011 (http://www.SciRP.org/journal/jct) Bioengineering Functional Copolymers. XVII. Interaction of Organoboron Amide-Ester Branched Derivatives of Poly(Acrylic Acid) with Cancer Cells 1 2 3 4* 1 Mustafa Türk , Gülten Kahraman , Sevda A. Khalilova , Zakir M. O. Rzayev , Serpil Oguztüzün 1Department of Biology, Faculty of Arts and Sciences, Kırıkkale University, Yahşihan, Turkey; 2Sarayköy Nuclear Research and Training Center, Turkish Atomic Energy Authority, Ankara, Turkey; 3Scientific Research Institute of Medicinal Prophylaxis, Minis- try of Public Health, Baku, Azerbaijan; 4Institute of Science Engineering, Division of Nanoscience and Nanomedicine, Hacettepe University, Ankara, Turkey. Email: zmo@.tr Received January 11th, 2011; revised May 20th, 2011; accepted May 30th, 2011. ABSTRACT Novel bioengineering functional organoboron polymers were synthesized by 1) amidolysis of poly(acrcylic acid) (PAA) with 2-aminoethyldiphenyl borinate (2-AEPB), 2) esterification of organoboron PAA polymer (PAA-B) with -hydroxy--methoxypoly(ethylene oxide) (PEO) as a compatibilizer and 3) conjugation of organoboron PEO branches (PAA-B-PEO) with folic acid (FA) as a targeting agent. Structure and composition of the synthesized poly- 1 13 mers were characterized by FTIR-ATR and H ( C) NMR spectroscopy, chemical and physical analysis methods. Anti- tumor activity of organoboron functional polymer and its complex with FA (PAA-B-PEO-F) against cancer and normal cells were evaluated by using different biochemical methods such as cytotoxicity, statis