cytokines and metabolic patterns in pediatric patients with critical illness在儿科患者细胞因子和代谢模式重要的疾病.pdfVIP

Hindawi Publishing Corporation Clinical and Developmental Immunology Volume 2010, Article ID 354047, 11 pages doi:10.1155/2010/354047 Clinical Study Cytokines and Metabolic Patterns in Pediatric Patients with Critical Illness George Briassoulis,1, 2 Shekhar Venkataraman,1 and Ann Thompson1 1 Division of Pediatric Critical Care Medicine, Children’s Hospital of Pittsburgh of UPMC, 3705 Fifth Avenue, Pittsburgh, PA 15213, USA 2 Pediatric Intensive Care Unit, University Hospital of Heraklion, University of Crete, Voutes Area, Heraklion, 71110 Crete, Greece Correspondence should be addressed to George Briassoulis, ggbriass@otenet.gr Received 19 August 2009; Revised 21 December 2009; Accepted 22 February 2010 Academic Editor: Yasunobu Yoshikai Copyright © 2010 George Briassoulis et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. It is not known if cytokines, which are cell-derived mediators released during the host immune response to stress, affect metabolic response to stress during critical illness. The aim of this prospective study was to determine whether the metabolic response to stress is related to the inflammatory interleukin-6 (IL-6), 10 (IL-10), and other stress mediators’ responses and to assess their relationships with different feeding patterns, nutritional markers, the severity of illness as assessed by the Multiple Organ System Failure (MOSF), the Pediatric Risk of Mortality Score (PRISM), systemic inflammatory response syndrome (SIRS), and mortality in critically ill children. Patients were classified as hypermetaboli