developmental mechanisms in articular cartilage degradation in osteoarthritis发展机制在骨关节炎关节软骨退化.pdfVIP

Hindawi Publishing Corporation Arthritis Volume 2011, Article ID 683970, 16 pages doi:10.1155/2011/683970 Review Article Developmental Mechanisms in Articular Cartilage Degradation in Osteoarthritis Elena V. Tchetina Institute of Rheumatology, Russian Academy of Medical Sciences, Kashirskoye Shosse 34A, Moscow 115522, Russia Correspondence should be addressed to Elena V. Tchetina, etchetina@mail.ru Received 5 August 2010; Accepted 9 December 2010 Academic Editor: Henning Bliddal Copyright © 2011 Elena V. Tchetina. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Osteoarthritis is the most common arthritic condition, which involves progressive degeneration of articular cartilage. The most recent accomplishments have significantly advanced our understanding on the mechanisms of the disease development and progression. The most intriguing is the growing evidence indicating that extracellular matrix destruction in osteoarthritic articular cartilage resembles that in the hypertrophic zone of fetal growth plate during endochondral ossification. This suggests common regulatory mechanisms of matrix degradation in OA and in the development and can provide new approaches for the treatment of the disease by targeting reparation of chondrocyte phenotype. 1. Introduction it is believed that articular cartilage destruction in OA results from excessive loading, age-related changes, and metabolic Osteoarthritis (OA) is the most common joint disease, which imbalance in the tissue [ 11– 13].