dexamethasone prophylaxis in pediatric open heart surgery is associated with increased blood long pentraxin ptx3 potential clinical implications地塞米松预防小儿心内直视手术中增加血液长pentraxin ptx3潜在的临床意义.pdfVIP

Hindawi Publishing Corporation Clinical and Developmental Immunology Volume 2011, Article ID 730828, 6 pages doi:10.1155/2011/730828 Research Article Dexamethasone Prophylaxis in Pediatric Open Heart Surgery Is Associated with Increased Blood Long Pentraxin PTX3: Potential Clinical Implications Franco Lerzo,1 Giuseppe Peri,2 Andrea Doni,2 Paola Bocca,3 Fabio Morandi,3 Angela Pistorio,4 Anna Maria Carleo,1 Alberto Mantovani,2, 5 Vito Pistoia,3 and Ignazia Prigione3 1 Division of Cardiovascular Surgery, G. Gaslini Institute, IRCCS, Largo G. Gaslini 5, 16148 Genoa, Italy 2 Department of Immunology and Inflammation, Istituto Clinico Humanitas, IRCCS, Via Manzoni 56, 20089 Rozzano, Milan, Italy 3 Laboratory of Oncology, G. Gaslini Institute, IRCCS, Largo G. Gaslini 5, 16148 Genoa, Italy 4 Clinical Epidemiology and Biostatistics Unit, G. Gaslini Institute, IRCCS, Largo G. Gaslini 5, 16148 Genoa, Italy 5 Dipartimento di Medicina Traslazionale, University of Milan, Via Manzoni 56, 20089 Rozzano, Milan, Italy Correspondence should be addressed to Ignazia Prigione, ignaziaprigione@ospedale-gaslini.ge.it Received 12 November 2010; Accepted 2 May 2011 Academic Editor: Luigina Romani Copyright © 2011 Franco Lerzo et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Glucocorticoid administration before cardiopulmonary bypass (CPB) can reduce the systemic inflammatory response and improve clinical outcome. Long pentraxin PTX3 is a novel inflammatory parameter that could play a protective cardiovascular role by regulating inflammation. Twenty-nine children undergoing open heart surgery were enrolled in the stu