腹腔内感染细菌谱及耐药性分析.docVIP

腹腔内感染细菌谱及耐药性分析作者单位：516001 广东省惠州市中心人民医院 通讯作者：杨思敏 【摘要】 目的 探讨腹腔内感染的主要致病菌，并对其耐药性进行分析，为临床合理用药提供参考。方法 对2008年2月～2011年2月笔者所在医院住院患者送检的450份腹水标本进行细菌培养，并采用药敏一体化试剂盒进行药敏试验，分析细菌的耐药性。结果 共检出46例阳性标本，培养出60株菌株，其中革兰氏阴性菌占51.7%（31／60），革兰氏阳性菌占48.3%（29／60），两者百分比率相似。药敏试验发现，对革兰氏阴性杆菌有效的抗生素为亚胺培南，对革兰氏阳性菌有效的抗生素为克林霉素、万古霉素。结论 需不断检测腹腔内感染菌种变化及药物药敏情况，根据药敏试验合理选择抗生素及联合用药治疗。 【关键词】 腹腔内感染； 细菌； 耐药性 Infects the bacterium spectrum and the drug resistance analying YANG Si-min, CHEN Yuan.Guangdong Huizhou Center People’s Hospital,Huizhou 516001,China 【Abstract】 Objective In the goal discussion abdominal cavity infects the main pathogenic bacteria,and carried on the analysis to its drug resistance,provided the reference for the clinical reasonable medication.Methods The courtyard in hospital patient delivered 450 ascites specimens which from February 2008 to February 2011 examines to carry on the bacilliculture,and picked applies drugs the sensitive integrated reagent box to enter takes a walk the sensitive experiment,the analysis bacterium’s drug resistance.Results Altogether picked out 46 example masculine specimen,raised 60 strains,occupied primarily by the Gram-negative bacteria 51.7%（31/60）,next for the Gelanshi masculine fungus,occupied 48.3%（29/60） both were similar.South the medicine sensitive experiment discovery,cultivated to the Gelanshi negative bacillus effective antibiotic for the imines, to Gelanshi masculine fungus effective antibiotic for Kelin mildew element, eternal mildew element. The conclusion must examine in the abdominal cavity to infect the mold mushroom spawn change and the medicine medicine sensitive situation unceasingly,according to medicine sensitive experiment reasonable choice antibiotic and union medication treatment. 【Key words】 Abdominal cavity infects; Bacterium; Drug resistance 腹腔内感染是一种常见的外科急腹症，其发病率较高，重症者极易继发多功能器官衰竭而危及生命，是普外科的主要挑战之一。抗生素的使用对腹腔内感染的治疗起着至关重要的作用。但近年来，随着抗生素、糖皮质激素的滥用，细菌耐药现象日趋严重，加之细菌谱的变化，给临床治疗带来困难［1］。为合理、有效地选用抗生素，提高腹腔感染性疾病的治愈率，现对笔者所在医院2008年2月～201