原创力文档effects of fluctuating glucose concentrations on oxidative metabolism of glucose in cultured neurons and astroglia葡萄糖浓度波动对葡萄糖的氧化代谢的影响在培养神经元和星形神经胶质.pdfVIP
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effects of fluctuating glucose concentrations on oxidative metabolism of glucose in cultured neurons and astroglia葡萄糖浓度波动对葡萄糖的氧化代谢的影响在培养神经元和星形神经胶质
Vol.2, No.1, 19-26 (2012) Journal of Diabetes Mellitus
/10.4236/jdm.2012.21004
Effects of fluctuating glucose concentrations on
oxidative metabolism of glucose in cultured
neurons and astroglia
1* 2 1 1
Shinichi Takahashi , Takato Abe , Yoshikane Izawa , Norihiro Suzuki
1Department of Neurology, School of Medicine, Keio University, Tokyo, Japan; *Corresponding Author: takashin@tka.att.ne.jp
2Department of Internal Medicine, Tokyo Dental College, Ichikawa General Hospital, Chiba, Japan
Received 28 November 2011; revised 31 December 2011; accepted 13 January 2012
14 14
ABSTRACT Hyperglycemia; [ C]Acetate; [ C]Deoxyglucose;
14 14
[ C]Lactate; [ C]Pyruvate
The objective of the present study was to eva-
luate the effects of hyperglycemia on glucose
metabolism of brain cells. Not only a sustained 1. INTRODUCTION
hyperglycemic state, but also a fluctuating plas- Diabetes mellitus is a major risk factor of cardiovas-
ma glucose concentration has been implicated cular diseases [1]. Moreover, several population-based
in the pathogenesis of diabetic angiopathy. studies have revealed that diabetic patients suffer from
Acutely increasing plasma glucose levels have dementia more frequently than normal age-matched peo-
not been reported to alter glucose utilization of
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