effects of high-fat diets containing different fats on cholesterol metabolism in starvation-refeeding rats高脂肪饮食中含有不同的脂肪对胆固醇代谢的影响在starvation-refeeding老鼠.pdfVIP

Food and Nutrition Sciences, 2011, 2, 647-654 647 doi:10.4236/fns.2011.26090 Published Online August 2011 (http://www.SciRP.org/journal/fns) Effects of High-Fat Diets Containing Different Fats on Cholesterol Metabolism in Starvation-Refeeding Rats 1 2* Reiko Inai , Tatsuhiro Matsuo 1Department of Health and Nutritional Science, Nagoya Keizai University, Aichi, Japan; 2Faculty of Agriculture, Kagawa University, Kagawa, Japan. * Email: matsuo@ag.kagawa-u.ac.jp Received June 18th, 2011; revised July 12th, 2011; accepted July 19th, 2011. ABSTRACT The present study was performed to investegate the effects of high-fat diets containing different fats on cholesterol me- tabolism in starvation-refeeding rats. Forty female Donryu rats were divided into two groups and then fed high-fat diets containing beef tallow or corn oil without cholesterol for 14 days. Then, 10 rats from each group were divided into high-cholesterol and cholesterol-free groups (Experiment 1). Another 10 rats from beef tallow and corn oil groups were divided into high-cholesterol and high-cholesterol-cholestyramine groups (Experiment 2). All rats were fasted for 2 days followed by 3 days of feeding. In Experiment 1, the high-cholesterol diet caused significant increases in plasma total cholesterol and cholesteryl ester concentrations in the beef tallow diet group. In Experiment 2, dietary cho- lestyramine markedly decreased plasma and liver cholesterol levels; however, these cholesterol levels were higher in the beef tallow diet group even if cholestyramine was added to the diet. These results suggested that the cholesterol- lowering effect of dietary corn oil may not be due solely to reabsorption of bile acids. This study suggested that high-fat diets containing different fats affected choles