effects of parathyroid hormone on immune function甲状旁腺激素对免疫功能的影响.pdfVIP

Hindawi Publishing Corporation Clinical and Developmental Immunology Volume 2010, Article ID 418695, 10 pages doi:10.1155/2010/418695 Review Article Effects of Parathyroid Hormone on Immune Function Abdallah Sassine Geara,1 Mario R. Castellanos,1 Claude Bassil,1 Georgia Schuller-Levis,2 Eunkue Park,2 Marianne Smith,1 Michael Goldman,3 and Suzanne Elsayegh3 1 Department of Medicine, Staten Island University Hospital, 475 Seaview Avenue, Staten Island, NY 10305, USA 2 NYS Institute for Basic Research in Developmental Disabilities, 1050 Forest Hill Road, Staten Island, NY 10314, USA 3 Division of Nephrology, Staten Island University Hospital, 475 Seaview Avenue, Staten Island, NY 10305, USA Correspondence should be addressed to Abdallah Sassine Geara, abdallah.geara@ Received 13 March 2010; Accepted 15 June 2010 Academic Editor: Stuart Berzins Copyright © 2010 Abdallah Sassine Geara et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Parathyroid hormone (PTH) function as immunologic mediator has become interesting with the recent usage of PTH analogue (teriparatide) in the management of osteoporosis. Since the early 1980s, PTH receptors were found on most immunologic cells (neutrophils, B and T cells). The in vitro evaluations for a possible role of PTH as immunomodulator have shown inconsistent results mainly due to methodological heterogeneity of these studies: it used different PTH formulations (rat, bovine, and human), at different dosages and different incubating periods. In some of these studies, the lymphocytes were collected from uremic patients or animals, which renders the interpretation