高强度窄谱蓝光治疗面部寻常性痤疮临床观察.docVIP

高强度窄谱蓝光治疗面部寻常性痤疮临床观察［摘要］目的：观察高强度窄谱蓝光治疗面部寻常性痤疮的疗效。方法：应用波长为405～420nm的高强度窄谱蓝光治疗93例面部寻常性痤疮患者，每周2次，共治疗8次。计数患者炎性皮损（丘疹、脓疱、结节和囊肿）、非炎性皮损（粉刺）及皮损总数来计算改善率；观察患者治疗前后皮肤黑素指数、红斑指数、皮脂分泌及角质层含水量的变化情况。结果：治疗结束时，总有效率为82.80%。非炎性及炎性皮损平均改善率分别为51.67% 和68.90%；患者面部红斑指数及皮脂分泌显著降低，而黑素指数及角质层含水量与治疗前比较无显著变化。随访3个月，总有效率与治疗结束时相比差异无统计学意义。结论：高强度窄谱蓝光治疗面部寻常性痤疮疗效显著，且可以减轻皮肤红斑、减少皮脂分泌。 ［关键词］蓝光；寻常性痤疮；黑素指数；红斑指数；皮脂 [中图分类号]R758.73[文献标识码]A[文章编号]1008-6455（2007）10-1400-04 Treatment of facial acne vulgaris by a high-intensity,narrow-band blue light source LIU Mei1,LI Yuan-hong1,WU Yan1,DONG Guang-hui2,XU Yuan-yuan1,HE Chun-di1,CHEN Hong-Duo1 (1.Department of Dermatology of NO.1 Hospital，Key Laboratory of Immunodermatology of Ministry of Health, China Medical University, Shenyang 110001, Liaoning,China；2.Department of Biostatistics, China Medical University) Abstract：ObjectiveTo observe the efficacy of phototherapy with a high-intensity, narrow-band blue light source in patients with facial acne vulgaris. Methods Ninty-three patients with facial acne vulgaris were treated with the 405-420nm blue light, twice weekly for 4 weeks.The number of inflammatory lesions (papules, pustules, nodules and cysts),non-inflammatory lesions(comedones) and the total number were counted to evaluate the improvement.The changes of skin melanin index, erythema index, sebum secretion rate,corneum water content were observed before and after treatment. Results After the treatment,82.80%of the patients got more than 60% improvement. Mean percentage improvements after the final treatment in non-inflammatory and inflammatory lesions were 51.67% and 68.90%,respectively. At the 3-month follow-up visit, the global improvement did not change a lot.Erythema index, sebum secretion decreased significantly after the final treatment. However,melanin index and corneum water content remained at the level before the treatment. ConclusionBlue light treatment is effective for patients with facial acne vulgaris.It can also relieve the skin ery