原创力文档aging increases oxidative stress and renal expression of oxidant and antioxidant enzymes that are associated with an increased trend in systolic blood pressure增加氧化应激和老化肾氧化剂和抗氧化酶的表达与收缩压增加趋势.pdfVIP
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aging increases oxidative stress and renal expression of oxidant and antioxidant enzymes that are associated with an increased trend in systolic blood pressure增加氧化应激和老化肾氧化剂和抗氧化酶的表达与收缩压增加趋势
[Oxidative Medicine and Cellular Longevity 2:3, 138-145; July/August 2009]; ©2009 Landes Bioscience
Research Paper
Aging increases oxidative stress and renal expression of oxidant
and antioxidant enzymes that are associated with an increased trend
in systolic blood pressure
Pedro Gomes, Sónia Simão, Elisabete Silva, Vanda Pinto, João S. Amaral, Joana Afonso, Maria Paula Serrão, Maria
João Pinho and Patrício Soares-da-Silva*
Institute of Pharmacology and Therapeutics; Faculty of Medicine; University of Porto; Porto, Portugal
Abbreviations: DTT, dithiothreitol; EDTA, ethylene diamine tetra-acetic acid; GAPDH, glyceraldehyde-3-phosphate dehydrogenase;
GPx, glutathione peroxidase; H O , hydrogen peroxide; HEPES, 4-(2-hydroxyethyl)-1-piperazine ethanesulfonic acid; MDA, malondi-
2 2
aldehyde; NADPH, nicotinamide adenine dinucleotide phosphate; Nox, NADPH oxidase; ROS, reactive oxygen species; SDS,
sodium dodecyl sulfate polyacrylamide gel electrophoresis; SHR, spontaneously hypertensive rat; SOD, superoxide dismutase; TBA,
thiobarbituric acid; TCA, trichloroacetic acid; WKY, Wistar Kyoto
Key words: aging, oxidative stress, kidney, hydrogen peroxide, NADPH oxidase, antioxidant enzymes, Wistar Kyoto rat
The aim of this study was to investigate whether the effects or marked increases in blood pressure. It is hypothesized that
of aging on oxidative stress markers and expression of major lack of oxidative stress-associated effects in aged WKY rats may
oxidant and antioxidant enzymes associate with impairment result from increases in antioxidant defenses that counteract the
of renal function and increases in blood pressure. To explore damaging effects of H O .
2
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