the effect of carotid plaque morphology on longitudinal fibrous cap stress levels颈动脉斑块形态的影响在纵向纤维帽的压力.pdfVIP

World Journal of Mechanics, 2012, 2, 216-223 doi:10.4236/wjm.2012.24026 Published Online August 2012 (http://www.SciRP.org/journal/wjm) The Effect of Carotid Plaque Morphology on Longitudinal Fibrous Cap Stress Levels 1,2 1 2 2 Samuel A. Thrysøe , Anders F. Stegmann , Nikolaj Eldrup , Anette Klærke , William Paaske2, Won Yong Kim1,3, Jens V. Nygaard4 1MR-Center, Aarhus University Hospital, Aarhus, Denmark 2Department of Cardiothoracic and Vascular Surgery T, Aarhus University Hospital, Aarhus, Denmark 3Department of Cardiology, Aarhus University Hospital, Aarhus, Denmark 4Aarhus School of Engineering, Aarhus University, Aarhus, Denmark Email: samuel@mr.au.dk Received May 29, 2012; revised June 30, 2012; accepted July 11, 2012 ABSTRACT Background and Purpose : Rupture of vulnerable carotid atherosclerotic plaques is a major cause of stroke. Stress levels may reflect risk of rupture in patients with carotid atherosclerotic plaques. Features thought to influence the risk of plaque rupture include the degree of stenosis, lipid-rich necrotic core (LR-NC) size, and thickness of the protective fi- brous caps. We used computational models to investigate the effect of these variables on fibrous cap stress levels. Methods : Two-way coupled fluid-structure interaction longitudinal 2D simulations were performed on a bifurcation model based on idealized geometry derived from a symptomatic patient. Models with varying degrees of stenosis (50%