慢性阻塞性肺疾病测定甲状腺激素临床意义.docVIP

慢性阻塞性肺疾病测定甲状腺激素临床意义[摘要] 目的：研究血清甲状腺激素水平与老年慢性阻塞性肺疾病患者病情变化的关系，探讨其临床意义。方法：检测115例老年慢性阻塞性肺疾病患者（观察组）治疗前后血清甲状腺激素水平，并与115例健康体检者（对照组）进行对照分析。结果：老年慢性阻塞性肺疾病急性加重期患者血清TT3、FT4、TSH明显低于正常对照组，差异有统计学意义（P0.05），老年慢性阻塞性肺疾病急性加重期患者经治疗好转后血清TT3、FT3比治疗前明显升高，差异有统计学意义（P0.05）。结论：甲状腺激素水平与慢性阻塞性肺疾病的严重性、进展和预后有一定的关系，检测甲状腺激素水平可用于评估慢性阻塞性肺疾病急性加重期患者的病情。 [关键词] 慢性阻塞性肺疾病 甲状腺素 测定 [中图分类号] R563.3[文献标识码]A[文章编号]1673-7210（2011）02（b）-024-02 The clinical significance of determining thyroid hormone in chronic obstructive pulmonary diseases LI Zhiguan1, HE Bingwen2, ZHU Daqing3 (The First People’s Hospital of Chenzhou City, Hu′nan Province, Chenzhou 423000, China) [Abstract] Objective: To study the relationship between the levels of thyroid hormone in elderly patients with chronic obstructive pulmonary disease and the changes of disease, and explore its clinical significance. Methods: The serum thyroid hormone levels of 115 patients with chronic obstructive pulmonary disease (observation group) before and after treatment were determined, and compared with those of 115 healthy subjects (control group). Results: Serum TT3, FT4, TSH of elderly patients with chronic obstructive pulmonary disease were significantly lower than those of the control group, the difference was statistically significant (P0.05). After the improvement of chronic obstructive pulmonary disease, the serum TT3, FT3 of patients were significantly higher than those before treatment, the difference was statistically significant (P0.05). Conclusion: The level of thyroid hormone has a certain relationship with the severity, progression and prognosis of chronic obstructive pulmonary disease, and determining thyroid hormone can be used to assess the conditions of patients with chronic obstructive pulmonary disease in acute exacerbation stage. [Key words ] Chronic obstructive pulmonary disease; Thyroxine; Determination 慢性阻塞性肺疾病（COPD）是一种破坏性的肺部疾病，是以不完全可逆的气流受阻为特征，危及人类生命安全的常见病和多发病，其患病率和病死率均较高。有关研究数据显示，我国40岁以上人口COPD患病率为8.2%[1]。估计全国有4 000万例